Open Access

Increased abundance of Firmicutes and depletion of Bacteroidota predicts poor outcome in chronic lymphocytic leukemia

  • Authors:
    • Magdalena Paziewska
    • Monika Szelest
    • Michał Kiełbus
    • Marta Masternak
    • Joanna Zaleska
    • Ewa Wawrzyniak
    • Aleksandra Kotkowska
    • Monika Siemieniuk-Ryś
    • Marta Morawska
    • Elżbieta Kalicińska
    • Paula Jabłonowska
    • Tomasz Wróbel
    • Anna Wolska-Washer
    • Jerzy Zdzisław Błoński
    • Tadeusz Robak
    • Lars Bullinger
    • Krzysztof Giannopoulos
  • View Affiliations

  • Published online on: September 17, 2024     https://doi.org/10.3892/ol.2024.14685
  • Article Number: 552
  • Copyright : © Paziewska et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Evidence indicates that there are significant alterations in gut microbiota diversity and composition in patients with hematological malignancies. The present study investigated the oral and intestinal microbiome in patients with chronic lymphocytic leukemia (CLL) (n=81) and age‑matched healthy volunteers (HVs; n=21) using 16S ribosomal RNA next‑generation sequencing. Changes in both oral and gut microbiome structures were identified, with a high abundance of Proteobacteria and depletion of Bacteroidetes in CLL as compared to HVs. Oral and stool samples of patients with CLL revealed a significant change in the abundance of short‑chain fatty acid‑producing genera in comparison with HVs. Furthermore, the relative abundance of oral and intestine Bacteroidetes was significantly decreased in patients with CLL with negative prognostic features, including unmutated immunoglobulin heavy chain gene (IGHV). Notably, an increased abundance of gut Firmicutes was found to be associated with high expression of CD38. Finally, the present study suggested the log Firmicutes/Bacteroidota ratio as a novel intestinal microbiome signature associated with a shorter time to first treatment in individuals with CLL. The findings indicate that oral and gut microbial diversity in CLL might point to the inflammatory‑related modulation of the clinical course of the disease.
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November-2024
Volume 28 Issue 5

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Spandidos Publications style
Paziewska M, Szelest M, Kiełbus M, Masternak M, Zaleska J, Wawrzyniak E, Kotkowska A, Siemieniuk-Ryś M, Morawska M, Kalicińska E, Kalicińska E, et al: Increased abundance of <em>Firmicutes</em> and depletion of <em>Bacteroidota</em> predicts poor outcome in chronic lymphocytic leukemia. Oncol Lett 28: 552, 2024.
APA
Paziewska, M., Szelest, M., Kiełbus, M., Masternak, M., Zaleska, J., Wawrzyniak, E. ... Giannopoulos, K. (2024). Increased abundance of <em>Firmicutes</em> and depletion of <em>Bacteroidota</em> predicts poor outcome in chronic lymphocytic leukemia. Oncology Letters, 28, 552. https://doi.org/10.3892/ol.2024.14685
MLA
Paziewska, M., Szelest, M., Kiełbus, M., Masternak, M., Zaleska, J., Wawrzyniak, E., Kotkowska, A., Siemieniuk-Ryś, M., Morawska, M., Kalicińska, E., Jabłonowska, P., Wróbel, T., Wolska-Washer, A., Błoński, J. Z., Robak, T., Bullinger, L., Giannopoulos, K."Increased abundance of <em>Firmicutes</em> and depletion of <em>Bacteroidota</em> predicts poor outcome in chronic lymphocytic leukemia". Oncology Letters 28.5 (2024): 552.
Chicago
Paziewska, M., Szelest, M., Kiełbus, M., Masternak, M., Zaleska, J., Wawrzyniak, E., Kotkowska, A., Siemieniuk-Ryś, M., Morawska, M., Kalicińska, E., Jabłonowska, P., Wróbel, T., Wolska-Washer, A., Błoński, J. Z., Robak, T., Bullinger, L., Giannopoulos, K."Increased abundance of <em>Firmicutes</em> and depletion of <em>Bacteroidota</em> predicts poor outcome in chronic lymphocytic leukemia". Oncology Letters 28, no. 5 (2024): 552. https://doi.org/10.3892/ol.2024.14685