Open Access

Personalized combination therapy for diffuse midline glioma: A case report

  • Authors:
    • Mengqi Sun
    • Jizhou Zheng
    • Long Gong
    • Zihuang Li
    • Lijun Wang
  • View Affiliations

  • Published online on: March 17, 2025     https://doi.org/10.3892/ol.2025.14980
  • Article Number: 234
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to analyze the efficacy of personalized combination therapy for patients with H3K27M mutant diffuse midline glioma (DMG) so as to explore new treatment options for further clinical research. The clinical data and prognosis of a patient with H3K27M mutant DMG are summarized and discussed in the context of the relevant literature. The patient was a 20‑year‑old female diagnosed with DMG treated with a combination of surgery, radiotherapy, chemotherapy, electric field therapy, immunotherapy and targeted therapy. An overall survival time of 28 months was achieved. In summary, personalized treatment strategies are expected to provide longer‑lasting survival benefits for patients with DMG.
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May-2025
Volume 29 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Sun M, Zheng J, Gong L, Li Z and Wang L: Personalized combination therapy for diffuse midline glioma: A case report. Oncol Lett 29: 234, 2025.
APA
Sun, M., Zheng, J., Gong, L., Li, Z., & Wang, L. (2025). Personalized combination therapy for diffuse midline glioma: A case report. Oncology Letters, 29, 234. https://doi.org/10.3892/ol.2025.14980
MLA
Sun, M., Zheng, J., Gong, L., Li, Z., Wang, L."Personalized combination therapy for diffuse midline glioma: A case report". Oncology Letters 29.5 (2025): 234.
Chicago
Sun, M., Zheng, J., Gong, L., Li, Z., Wang, L."Personalized combination therapy for diffuse midline glioma: A case report". Oncology Letters 29, no. 5 (2025): 234. https://doi.org/10.3892/ol.2025.14980