Open Access

Role of antidiarrheal agents nifuroxazide in antitumor multi‑target anticancer, multi‑mechanism anticancer drug (Review)

  • Authors:
    • Liping Liu
    • Chengshan Ma
    • Jinfeng Ji
    • Rong Gao
    • Deliang Li
  • View Affiliations

  • Published online on: April 2, 2025     https://doi.org/10.3892/ol.2025.15006
  • Article Number: 260
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Nifuroxazide (NFZ) is an antimicrobial drug, which has been found to be a promising antitumor agent in recent years. In addition to being a classic STAT3 inhibitor, NFZ can also act on IL‑6 and exert an anti‑tumor role through inflammatory factor pathways. It can also bind to target proteins of aldehyde dehydrogenase 1, one of the families of E‑twenty‑six transcription factors and ubiquitin‑specific protease 21 to play an anti‑tumor role in different pathways. NFZ is able to act on the tumor cell microenvironment to inhibit tumor angiogenesis and tumor cell migration, enhance tumor immune cells, increase the cytotoxicity of tumor cells and enhance the anti‑tumor effect of other drugs. Furthermore, it has high safety with few toxic side effects. The anti‑tumor mechanisms of NFZ were described in the current review, aiming to provide insight and a reference for future studies promoting the implementation of NFZ as an anti‑tumor drug in the clinic.
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June-2025
Volume 29 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Liu L, Ma C, Ji J, Gao R and Li D: Role of antidiarrheal agents nifuroxazide in antitumor multi‑target anticancer, multi‑mechanism anticancer drug (Review). Oncol Lett 29: 260, 2025.
APA
Liu, L., Ma, C., Ji, J., Gao, R., & Li, D. (2025). Role of antidiarrheal agents nifuroxazide in antitumor multi‑target anticancer, multi‑mechanism anticancer drug (Review). Oncology Letters, 29, 260. https://doi.org/10.3892/ol.2025.15006
MLA
Liu, L., Ma, C., Ji, J., Gao, R., Li, D."Role of antidiarrheal agents nifuroxazide in antitumor multi‑target anticancer, multi‑mechanism anticancer drug (Review)". Oncology Letters 29.6 (2025): 260.
Chicago
Liu, L., Ma, C., Ji, J., Gao, R., Li, D."Role of antidiarrheal agents nifuroxazide in antitumor multi‑target anticancer, multi‑mechanism anticancer drug (Review)". Oncology Letters 29, no. 6 (2025): 260. https://doi.org/10.3892/ol.2025.15006