Pancreatic liposarcoma: A case report

Zhao,Yan; Hu,Shikang; Sun,Huajun; Yang,Jiyun; Lu,Tao

doi:10.3892/ol.2025.15014

Pancreatic liposarcoma: A case report

Authors:
- Yan Zhao
- Shikang Hu
- Huajun Sun
- Jiyun Yang
- Tao Lu
View Affiliations

Affiliations: Department of Radiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China, Department of Radiology, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, P.R. China, Department of Pathology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China, Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center of Medical Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China
Published online on: April 7, 2025 https://doi.org/10.3892/ol.2025.15014
Article Number: 268
Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Primary liposarcoma (LPS) of the pancreas is extremely rare. The present report describes an additional case of primary pancreatic LPS and reviews the current literature. A 40‑year‑old female patient that initially presented with a fever was subsequently found to have a pancreatic tumor. CT was used to identify a heterogeneous mass in the pancreatic head and body, which had a notable absence of fat components. The tumor exhibited slightly heterogeneous enhancement during the arterial phase, moderate enhancement in the venous phase and persistent enhancement in the delayed phase, with encapsulation of the common hepatic artery, splenic vein and portal vein. The patient underwent a successful distal pancreatectomy and splenectomy. Pathological examination and next‑generation sequencing confirmed the diagnosis of dedifferentiated LPS (DDLPS). The present report elucidated the CT findings of this rare case of DDLPS of the pancreas, characterized by vascular invasion and progressive enhancement but without fat components, which can serve as a reference for the diagnosis of this uncommon tumor. The uncommon CT manifestation makes differentiation from pancreatic neuroendocrine tumors particularly challenging based on imaging characteristics.

View Figures

View References

1	Ardakani AHG, Woollard A, Ware H and Gikas P: Soft tissue sarcoma: Recognizing a rare disease. Cleve Clin J Med. 89:73–80. 2022. View Article : Google Scholar : PubMed/NCBI
2	Bourcier K, Le Cesne A, Tselikas L, Adam J, Mir O, Honore C and de Baere T: Basic knowledge in soft tissue sarcoma. Cardiovasc Intervent Radiol. 42:1255–1261. 2019. View Article : Google Scholar : PubMed/NCBI
3	Gamboa AC, Gronchi A and Cardona K: Soft-tissue sarcoma in adults: An update on the current state of histiotype-specific management in an era of personalized medicine. CA Cancer J Clin. 70:200–229. 2020. View Article : Google Scholar : PubMed/NCBI
4	Gilbert NF, Cannon CP, Lin PP and Lewis VO: Soft-tissue sarcoma. J Am Acad Orthop Surg. 17:40–47. 2009. View Article : Google Scholar : PubMed/NCBI
5	Lee ATJ, Thway K, Huang PH and Jones RL: Clinical and molecular spectrum of liposarcoma. J Clin Oncol. 36:151–159. 2018. View Article : Google Scholar : PubMed/NCBI
6	Sbaraglia M, Bellan E and Dei Tos AP: The 2020 WHO classification of soft tissue tumours: News and perspectives. Pathologica. 113:70–84. 2020. View Article : Google Scholar : PubMed/NCBI
7	Thway K: Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review. Semin Diagn Pathol. 36:112–121. 2019. View Article : Google Scholar : PubMed/NCBI
8	Dehner CA, Hagemann IS and Chrisinger JSA: Retroperitoneal dedifferentiated liposarcoma. Am J Clin Pathol. 156:920–925. 2021. View Article : Google Scholar : PubMed/NCBI
9	Kammerer-Jacquet SF, Thierry S, Cabillic F, Lannes M, Burtin F, Henno S, Dugay F, Bouzillé G, Rioux-Leclercq N, Belaud-Rotureau MA and Stock N: Differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: Utility of p16 in combination with MDM2 and CDK4 immunohistochemistry. Hum Pathol. 59:34–40. 2017. View Article : Google Scholar : PubMed/NCBI
10	Tanabe M, Matsui H, Higashi M, Tokumitsu Y, Nagano H and Ito K: Pancreatic liposarcoma: A case report. Abdom Radiol (NY). 47:1912–1916. 2022. View Article : Google Scholar : PubMed/NCBI
11	Liu Z, Fan WF, Li GC, Long J, Xu YH and Ma G: Huge primary dedifferentiated pancreatic liposarcoma mimicking carcinosarcoma in a young female: A case report. World J Clin Cases. 7:1344–1350. 2019. View Article : Google Scholar : PubMed/NCBI
12	Han T, Luan Y, Xu Y, Yang X, Li J, Liu R, Li Q and Zheng Z: Successful treatment of advanced pancreatic liposarcoma with apatinib: A case report and literature review. Cancer Biol Ther. 18:635–639. 2017. View Article : Google Scholar : PubMed/NCBI
13	Machado MCC, Fonseca GM, de Meirelles LR, Zacchi FFS and Bezerra ROF: Primary liposarcoma of the pancreas: A review illustrated by findings from a recent case. Pancreatology. 16:715–718. 2016. View Article : Google Scholar : PubMed/NCBI
14	Matthews M, Nelson S, Hari D and French S: Well differentiated liposarcoma, sclerosing type, of the pancreas a case report. Exp Mol Pathol. 101:320–322. 2016. View Article : Google Scholar : PubMed/NCBI
15	Dodo IM, Adamthwaite JA, Jain P, Roy A, Guillou PJ and Menon KV: Successful outcome following resection of a pancreatic liposarcoma with solitary metastasis. World J Gastroenterol. 11:7684–7685. 2005. View Article : Google Scholar : PubMed/NCBI
16	Cao D, Wang J and Guo L: Pancreatic liposarcoma: A rare cause of pancreatic mass in adult. J Gastroenterol Hepatol. 34:12752019. View Article : Google Scholar : PubMed/NCBI
17	Kuramoto K, Hashimoto D, Abe S, Chikamoto A, Beppu T, Iyama K and Baba H: Hepatobiliary and pancreatic: Large pancreatic liposarcoma. J Gastroenterol Hepatol. 28:18002013. View Article : Google Scholar : PubMed/NCBI
18	Elliott TE, Albertazzi VJ and Danto LA: Pancreatic liposarcoma. Case report with review of retroperitoneal liposarcomas. Cancer. 45:1720–1723. 1980. View Article : Google Scholar : PubMed/NCBI
19	Improta L, Pasquali S, Iadecola S, Barisella M, Fiore M, Radaelli S, Colombo C, Alloni R, Callegaro D, Valeri S, et al: Organ infiltration and patient risk after multivisceral surgery for primary retroperitoneal liposarcomas. Ann Surg Oncol. 30:4500–4510. 2023. View Article : Google Scholar : PubMed/NCBI
20	Tyler R, Wanigasooriya K, Taniere P, Almond M, Ford S, Desai A and Beggs A: A review of retroperitoneal liposarcoma genomics. Cancer Treat Rev. 86:1020132020. View Article : Google Scholar : PubMed/NCBI
21	Coindre JM, Pédeutour F and Aurias A: Well-differentiated and dedifferentiated liposarcomas. Virchows Arch. 456:167–179. 2010. View Article : Google Scholar : PubMed/NCBI
22	Thway K, Flora R, Shah C, Olmos D and Fisher C: Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors. Am J Surg Pathol. 36:462–469. 2012. View Article : Google Scholar : PubMed/NCBI
23	Thway K, Wang J, Swansbury J, Min T and Fisher C: Fluorescence in situ hybridization for MDM2 amplification as a routine ancillary diagnostic tool for suspected well-differentiated and dedifferentiated liposarcomas: Experience at a tertiary center. Sarcoma. 2015:1–10. 2015. View Article : Google Scholar
24	Sirvent N, Coindre JM, Maire G, Hostein I, Keslair F, Guillou L, Ranchere-Vince D, Terrier P and Pedeutour F: Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: Utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR. Am J Surg Pathol. 31:1476–1489. 2007. View Article : Google Scholar : PubMed/NCBI
25	Xu L, Xie X, Shi X, Zhang P, Liu A, Wang J and Zhang B: Potential application of genomic profiling for the diagnosis and treatment of patients with sarcoma. Oncol Lett. 21:3532021. View Article : Google Scholar : PubMed/NCBI
26	Win TT, Jaafar H and Yusuf Y: Relationship of angiogenic and apoptotic activities in soft-tissue sarcoma. South Asian J Cancer. 3:171–174. 2020.PubMed/NCBI
27	Park BK, Koh HD, Won SY, Cho YS, Seo JH, An C and Park S: Suspicious findings observed retrospectively on CT imaging performed before the diagnosis of pancreatic cancer. J Gastrointest Oncol. 14:1008–1018. 2023. View Article : Google Scholar : PubMed/NCBI
28	He C, Zhu L, Wang X, Dai M, Wu H, Xu Q, Sun Z, Liu J, Xue H and Jin Z: Presumed radiological diagnosis of solid pseudopapillary tumors: Do we really know what we are watching? Pancreatology. 23:120–128. 2023. View Article : Google Scholar : PubMed/NCBI
29	Li DL, Li HS, Xu YK, Wang QS, Chen RY and Zhou F: Solid pseudopapillary tumor of the pancreas: Clinical features and imaging findings. Clin Imaging. 48:113–121. 2018. View Article : Google Scholar : PubMed/NCBI
30	Lo GC and Kambadakone A: MR imaging of pancreatic neuroendocrine tumors. Magn Reson Imaging Clin N Am. 26:391–403. 2018. View Article : Google Scholar : PubMed/NCBI
31	Wan Y, Hao H, Meng S, Li Z, Yu F, Chi M, Chao Q and Gao J: Application of low dose pancreas perfusion CT combined with enhancement scanning in diagnosis of pancreatic neuroendocrine tumors. Pancreatology. 21:240–245. 2021. View Article : Google Scholar : PubMed/NCBI
32	Perri G, Prakash LR and Katz MHG: Pancreatic neuroendocrine tumors. Curr Opin Gastroenterol. 35:468–477. 2019. View Article : Google Scholar : PubMed/NCBI
33	Srisajjakul S, Prapaisilp P and Bangchokdee S: CT and MR features that can help to differentiate between focal chronic pancreatitis and pancreatic cancer. Radiol Med. 125:356–364. 2020. View Article : Google Scholar : PubMed/NCBI
34	Crago AM and Dickson MA: Liposarcoma: Multimodality management and future targeted therapies. Surg Oncol Clin N Am. 25:761–773. 2016. View Article : Google Scholar : PubMed/NCBI
35	Gahvari Z and Parkes A: Dedifferentiated liposarcoma: Systemic therapy options. Curr Treat Options Oncol. 21:152020. View Article : Google Scholar : PubMed/NCBI
36	Amer KM, Congiusta DV, Thomson JE, Elsamna S, Chaudhry I, Bozzo A, Amer R, Siracuse B, Ghert M and Beebe KS: Epidemiology and survival of liposarcoma and its subtypes: A dual database analysis. J Clin Orthop Trauma. 11:S479–S484. 2020. View Article : Google Scholar : PubMed/NCBI