Open Access

Immunotherapy for primary squamous cell carcinoma of the liver: A case report

  • Authors:
    • Jian Jiang
    • Guomin Dong
    • Suoni Li
    • Jiequn Ma
    • Jie Bai
    • Jinzi Hui
    • Hongbian Gao
    • Zheng Zhao
  • View Affiliations

  • Published online on: April 7, 2025     https://doi.org/10.3892/ol.2025.15025
  • Article Number: 279
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study reports an exceedingly rare case of primary squamous cell carcinoma of the liver (PSCCL), a malignancy that has been documented in only ~30 cases worldwide, with both diagnosis and treatment presenting significant challenges. A 72‑year‑old man presented with right upper abdominal discomfort was admitted to Shaanxi Provincial Cancer Hospital (Xi'an, China). Computed tomography (CT) imaging revealed a space‑occupying lesion in the liver. A subsequent percutaneous liver biopsy confirmed a diagnosis of PSCCL. Positron emission tomography/CT was performed to exclude metastasis from other primary sites and confirmed the diagnosis of PSCCL. The patient received combination therapy of envafolimab and albumin‑paclitaxel plus cisplatin. Telephone follow‑up continued until December 2024 (a total of 18 months), during which the patient achieved and maintained a sustained partial response. The uniqueness of the present case lies in the patient's receipt of an innovative therapeutic regimen combining envafolimab with albumin‑paclitaxel and cisplatin, achieving a sustained partial response over an 18‑month follow‑up period. This outcome not only offers novel insights for the clinical management of PSCCL but also underscores the importance of multidisciplinary comprehensive treatment in rare tumors.
View Figures
View References

Related Articles

Journal Cover

June-2025
Volume 29 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Jiang J, Dong G, Li S, Ma J, Bai J, Hui J, Gao H and Zhao Z: Immunotherapy for primary squamous cell carcinoma of the liver: A case report. Oncol Lett 29: 279, 2025.
APA
Jiang, J., Dong, G., Li, S., Ma, J., Bai, J., Hui, J. ... Zhao, Z. (2025). Immunotherapy for primary squamous cell carcinoma of the liver: A case report. Oncology Letters, 29, 279. https://doi.org/10.3892/ol.2025.15025
MLA
Jiang, J., Dong, G., Li, S., Ma, J., Bai, J., Hui, J., Gao, H., Zhao, Z."Immunotherapy for primary squamous cell carcinoma of the liver: A case report". Oncology Letters 29.6 (2025): 279.
Chicago
Jiang, J., Dong, G., Li, S., Ma, J., Bai, J., Hui, J., Gao, H., Zhao, Z."Immunotherapy for primary squamous cell carcinoma of the liver: A case report". Oncology Letters 29, no. 6 (2025): 279. https://doi.org/10.3892/ol.2025.15025