Original and infiltrating patterns of prostatic carcinoma
- Authors:
- Nobuki Furubayashi
- Motonobu Nakamura
- Keniti Nishiyama
- Yoshihiro Hasegawa
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Affiliations:
Department of Urology, National Kyushu Cancer Centre, Fukuoka 811-1395, Japan. furubayashi.n@nk-cc.go.jp
- Published online on: January 1, 2010 https://doi.org/10.3892/ol_00000007
-
Pages:
41-44
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Abstract
In order to demonstrate the original and infiltrating patterns of prostatic carcinoma, the change of histological characteristics associated with increasing total cancer volume was investigated. Tissue specimens from 196 histopathological cases, obtained at the Kyushu Cancer Center, were reviewed in embedded whole-mount antegrade radical prostatectomy specimens with adenocarcinoma. Three groups (<0.5 cm3, ≤0.5 cm3 <1 cm3 and ≥1 cm3) of total cancer volume were identified and a histological study on each group was conducted based on the 2005 International Society of Urological Pathology Consensus Conference on Gleason Grading of Prostatic Carcinoma. With a cancer volume of <0.5 cm3, Gleason primary patterns 3 and 4 were observed in 64.4 and 26.7% of the tumors, respectively, while Gleason secondary patterns 3 and 4 were observed in 53.3 and 42.2%, respectively. The density of the acini was much higher in comparison with that of ambient normal acini. The percentage of acini, including cribriform carcinoma classified as Gleason pattern 3, increased significantly with the increase of cancer volume (p<0.01). The original pattern of the prostatic carcinoma was histologically composed of small acini of Gleason patterns 3 and 4 without forming a cribriform pattern. In addition, prostatic carcinoma infiltrated the surrounding stroma at a very early stage, thus infiltrating not only the stroma but also the preexisting ducts and acini, causing an increased cancer volume.
View References
|
1
|
Ekman P, Adolfsson J and Gronberg H: The
natural history of prostate cancer. Martin Dunitz; London: pp.
1–16. 1996
|
|
2
|
Elgamal AA, Van Poppel HP, Van De Voorde
WN, Van Dorpe JA, Oyen RH and Baert LV: Impalpable invisible stage
T1c prostate cancer: characteristics and clinical relevance in 100
radical prostatectomy specimens - a different view. J Urol.
157:244–250. 1997. View Article : Google Scholar
|
|
3
|
Epstein JI, Allsbrook WC Jr, Amin MB and
Egevad LL; the ISUP Grading Committee. The 2005 International
Society of Urological Pathology (ISUP) Consensus Conference on
Gleason Grading of Prostatic Carcinoma. Am J Surg Pathol.
29:1228–1242. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
McNeal JE, Villers AA, Redwine EA, Freiha
FS and Stamey TA: Histologic differentiation, cancer volume and
pelvic lymph node metastasis in adenocarcinoma of the prostate.
Cancer. 66:1225–1233. 1990.PubMed/NCBI
|
|
5
|
Stamey TA, Freiha FS, McNeal JE, et al:
Localized prostate cancer: relationship of tumor volume to clinical
significance for treatment of prostate cancer. Cancer. 71:933–938.
1993.PubMed/NCBI
|
|
6
|
Humphrey PA: Natural history and
mortality. Prostate Pathology. Amer Society of Clinical Pathology;
Chicago: pp. 241–249. 2003
|
|
7
|
Bailar JC III, Mellinger GT and Gleason
DF: Survival rates of patients with prostatic cancer, tumor stage
and differentiation: preliminary report. Cancer Chemother Rep.
50:129–136. 1966.PubMed/NCBI
|
|
8
|
Gleason DF: Classification of prostatic
carcinomas. Cancer Chemother Rep. 50:125–128. 1966.PubMed/NCBI
|
|
9
|
Mellinger GT, Gleason D and Bailar JC III:
The histology and prognosis of prostatic cancer. J Urol.
97:331–337. 1967.PubMed/NCBI
|
|
10
|
Kovi J, Jackson MA and Heshmat MY: Ductal
spread in prostatic carcinoma. Cancer. 56:1566–1573. 1985.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
McNeal JE, Reese JH, Redwine EA, Freiha FS
and Stamey TA: Cribriform adenocarcinoma of the prostate. Cancer.
58:1714–1719. 1986. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
McNeal JE and Cheryl EM: Spread of
adenocarcinoma within prostatic ducts and acini. Am J Surg Pathol.
20:802–814. 1996. View Article : Google Scholar : PubMed/NCBI
|
