1
|
Semenza GL: HIF-1 and mechanisms of
hypoxia sensing. Curr Opin Cell Biol. 13:167–171. 2001. View Article : Google Scholar : PubMed/NCBI
|
2
|
Volm M and Koomagi R: Hypoxia-inducible
factor (HIF-1) and its relationship to apoptosis and proliferation
in lung cancer. Anticancer Res. 20:1527–1533. 2000.PubMed/NCBI
|
3
|
Zhong H, Mabjeesh N, Willard M and Simons
J: Nuclear expression of hypoxia-inducible factor 1alpha protein is
heterogeneous in human malignant cells under normoxic conditions.
Cancer Lett. 181:233–238. 2002. View Article : Google Scholar : PubMed/NCBI
|
4
|
Jubb AM, Pham TQ, Hanby AM, et al:
Expression of vascular endothelial growth factor, hypoxia inducible
factor 1alpha, and carbonic anhydrase IX in human tumours. J Clin
Pathol. 57:504–512. 2004. View Article : Google Scholar : PubMed/NCBI
|
5
|
Osada R, Horiuchi A, Kikuchi N, Yoshida J,
Hayashi A and Ota M: Expression of hypoxia-inducible factor 1alpha,
hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in
epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau
gene: nuclear expression of hypoxia-inducible factor 1alpha is an
independent prognostic factor in ovarian carcinoma. Hum Pathol.
38:1310–1320. 2007.
|
6
|
Yoshimura H, Dhar DK, Kohno H, et al:
Prognostic impact of hypoxia-inducible factors 1{alpha} and
2{alpha} in colorectal cancer patients: correlation with tumor
angiogenesis and cyclooxygenase-2 expression. Clin Cancer Res.
10:8554–8560. 2004.
|
7
|
Kubo T, Sugita T, Shimose S, Matsuo T,
Arihiro K and Ochi M: Expression of hypoxia-inducible
factor-1{alpha} and its relationship to tumour angiogenesis and
cell proliferation in cartilage tumours. J Bone Joint Surg Br.
90B:364–370. 2008.
|
8
|
Wiesener MS, Jurgensen JS, Rosenberger C,
et al: Widespread, hypoxia-inducible expression of HIF-2alpha in
distinct cell populations of different organs. FASEB J. 17:271–273.
2003.PubMed/NCBI
|
9
|
Rankin EB and Giaccia AJ: The role of
hypoxia-inducible factors in tumorigenesis. Cell Death Differ.
15:678–685. 2008. View Article : Google Scholar : PubMed/NCBI
|
10
|
Ameri K, Lewis CE, Raida M, Sowter H, Hai
T and Harris AL: Anoxic induction of ATF-4 through
HIF-1-independent pathways of protein stabilization in human cancer
cells. Blood. 103:1876–1882. 2004. View Article : Google Scholar : PubMed/NCBI
|
11
|
Shi YH, Wang YX, Bingle L, et al: In vitro
study of HIF-1 activation and VEGF release by bFGF in the T47D
breast cancer cell line under normoxic conditions: involvement of
PI-3K/Akt and MEK1/ERK pathways. J Pathol. 205:530–536. 2005.
View Article : Google Scholar : PubMed/NCBI
|
12
|
Zagzag D, Zhong H, Scalzitti JM, Laughner
E, Simons JW and Semenza GL: Expression of hypoxia-inducible factor
1 alpha in brain tumors – association with angiogenesis, invasion,
and progression. Cancer. 88:2606–2618. 2000.
|
13
|
Gillespie DL, Zhong H, Scalzitti JM,
Laughner E, Simons JW and Semenza GL: Silencing of hypoxia
inducible factor-1alpha by RNA interference attenuates human glioma
cell growth in vivo. Clin Cancer Res. 15:2441–2448. 2007.
View Article : Google Scholar : PubMed/NCBI
|
14
|
Kilic M, Kasperczyk H, Fulda S and Debatin
KM: Role of hypoxia inducible factor-1 alpha in modulation of
apoptosis resistance. Oncogene. 26:2027–2038. 2007. View Article : Google Scholar : PubMed/NCBI
|
15
|
Zhang X, Kon T, Wang H, et al: Enhancement
of hypoxia-induced tumor cell death in vitro and radiation therapy
in vivo by use of small interfering RNA targeted to
hypoxia-inducible factor-1{alpha}. Cancer Res. 64:8139–8142.
2004.PubMed/NCBI
|
16
|
Krick S, Eul BG, Hanze J, et al: Role of
hypoxia-inducible factor-1{alpha} in hypoxia-induced apoptosis of
primary alveolar epithelial type II cells. Cell Mol Biol.
32:395–403. 2005.
|
17
|
Mack FA, Rathmell WK, Arsham AM, Gnarra J,
Keith B and Simon MC: Loss of pVHL is sufficient to cause HIF
dysregulation in primary cells but does not promote tumor growth.
Cancer Cell. 3:75–88. 2003. View Article : Google Scholar : PubMed/NCBI
|
18
|
Lim JH, Park JW, Kim MS, Park SK, Johnson
RS and Chun YS: Bafilomycin induces the p21-mediated growth
inhibition of cancer cells under hypoxic conditions by expressing
hypoxia-inducible factor-1{alpha}. Mol Pharmacol. 70:1856–1865.
2006.PubMed/NCBI
|
19
|
Emerling BM, Platanias LC, Black E, et al:
Mitochondrial reactive oxygen species activation of p38
mitogen-activated protein kinase is required for hypoxia signaling.
Mol Cell Biol. 25:4853–4862. 2005. View Article : Google Scholar : PubMed/NCBI
|
20
|
Yoshida D, Kim K, Noha M and Teramoto A:
Anti-apoptotic action by hypoxia inducible factor 1-alpha in human
pituitary adenoma cell line, HP-75 in hypoxic condition. J
Neurooncol. 78:217–225. 2006. View Article : Google Scholar : PubMed/NCBI
|
21
|
Takahashi Y, Nishikawa M and Takakura Y:
Inhibition of tumor cell growth in the liver by RNA
interference-mediated suppression of HIF-1alpha expression in tumor
cells and hepatocytes. Gene Ther. 15:572–582. 2008. View Article : Google Scholar : PubMed/NCBI
|
22
|
Song Y, Wang W, Qu X and Sun S: Effects of
hypoxia inducible factor-1alpha (HIF-1alpha) on the growth and
adhesion in tongue squamous cell carcinoma cells. Indian J Med Res.
129:154–163. 2009.PubMed/NCBI
|
23
|
Yang JY, Walicki J, Michod D, Dubuis G and
Widmann C: Impaired akt activity down-modulation, caspase-3
activation, and apoptosis in cells expressing a caspase-resistant
mutant of RasGAP at position 157. Mol Biol Cell. 16:3511–3520.
2005. View Article : Google Scholar : PubMed/NCBI
|
24
|
Wei MC, Zong WX, Cheng EH, et al:
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial
dysfunction and death. Science. 292:727–730. 2001. View Article : Google Scholar : PubMed/NCBI
|
25
|
Scorrano L and Korsmeyer SJ: Mechanisms of
cytochrome c release by proapoptotic BCL-2 family members. Biochem
Biophys Res Commun. 304:437–444. 2003. View Article : Google Scholar : PubMed/NCBI
|
26
|
Amamoto K, Ichijo H and Korsmeyer SJ:
BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-Terminal
protein kinase pathway normally activated at G2/M. Mol Cell Biol.
19:8469–8478. 1999.PubMed/NCBI
|
27
|
Kondo E, Ichijo H and Korsmeyer SJ:
Expression of phosphorylated Ser70 of Bcl-2 correlates with
malignancy in human colorectal neoplasms. Clin Cancer Res.
11:7255–7263. 2005. View Article : Google Scholar : PubMed/NCBI
|
28
|
Blagosklonny MV, Schulte T, Nguyen P,
Trepel J and Neckers LM: Taxol-induced apoptosis and
phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a
novel c-Raf-1 signal transduction pathway. Cancer Res.
56:1851–1854. 1996.PubMed/NCBI
|