Apoptosis: Escaping strategies in human skin cancer (Review)
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- Published online on: February 1, 2004 https://doi.org/10.3892/or.11.2.401
- Pages: 401-405
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Abstract
Apoptosis must be considered a rescue mechanism that controls the integrity of the cell erasing aberrant clones and it is likely that failure of apoptosis constitutes a key factor responsible for tumour formation, progression and resistance to drugs. Several genes (e.g. survivin, bcl-2 family, p53) are involved in these pathways. Much work still needs to be done to identify the molecular pathway of apoptosis resistance but restoration of the apoptotic response represents a crucial new therapeutic target for cancer treatment.