Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer

  • Authors:
    • V. P.S. Garikapaty
    • B. T. Ashok
    • Y. G. Chen
    • A. Mittelman
    • M. Iatropoulos
    • R. K. Tiwari
  • View Affiliations

  • Published online on: January 1, 2005     https://doi.org/10.3892/or.13.1.89
  • Pages: 89-93
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Abstract

Indole-3-carbinol (I3C), a compound present as glucobracissin in cruciferous vegetables has anticancer activities which is in line with some of the epidemiological evidence that suggests a beneficial effect of consumption of cruciferous vegetables on cancer incidence and progression. The precise target of indole-3-carbinol has not been determined. We examined the effect of I3C on prostate cancer in a well-defined R3327 model using Copenhagen rats and the transplantable cell line, MAT-LyLu. This cell line derived from a tumor in Copenhagen rats is androgen independent and metastasizes to the lung and lymph nodes. Tumors were induced in Copenhagen rats by injecting MAT-LyLu subcutaneously and the animals treated with I3C that was administered either intraperitoneally or intravenously, in order to achieve maximal systemic exposure. This was a departure from the traditional chemopreventive route of indole-3-carbinol where the compound was incorporated in the diet. Our results indicate that I3C inhibited the incidence, growth and metastases of MAT-LyLu cells and both i.p. and i.v. injections of I3C were equally effective. Statistical analysis (Kaplan-Meier curves) clearly indicates a tumor-free and overall survival benefit as a result of treatment with I3C. These studies show for the first time that I3C in an injectible form has anti-prostate cancer activity.

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January 2005
Volume 13 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Garikapaty VP, Ashok BT, Chen YG, Mittelman A, Iatropoulos M and Tiwari RK: Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer . Oncol Rep 13: 89-93, 2005.
APA
Garikapaty, V.P., Ashok, B.T., Chen, Y.G., Mittelman, A., Iatropoulos, M., & Tiwari, R.K. (2005). Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer . Oncology Reports, 13, 89-93. https://doi.org/10.3892/or.13.1.89
MLA
Garikapaty, V. P., Ashok, B. T., Chen, Y. G., Mittelman, A., Iatropoulos, M., Tiwari, R. K."Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer ". Oncology Reports 13.1 (2005): 89-93.
Chicago
Garikapaty, V. P., Ashok, B. T., Chen, Y. G., Mittelman, A., Iatropoulos, M., Tiwari, R. K."Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer ". Oncology Reports 13, no. 1 (2005): 89-93. https://doi.org/10.3892/or.13.1.89