Differential expression and function of AR isoforms in prostate cancer

  • Authors:
    • Rui Zeng
    • Zhiyong Liu
    • Yinghao Sun
    • Chuanliang Xu
  • View Affiliations

  • Published online on: October 21, 2011     https://doi.org/10.3892/or.2011.1516
  • Pages: 492-498
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Abstract

The androgen receptor (AR) plays a key role in prostate cancer (PCa). Two isoforms of AR, are AR-A and -B, which differ by a lack of the first 187 amino acids in the NH2-terminal transactivation domain of AR-A. Since little is known about the expression and basic function of the AR-A/B isoforms in prostate cancer, the aim of this study was to analyze this possible association. The AR-A, -B and AR-A/B ratio was determined in the tissues of healthy controls, benign prostate hyperplasia (BPH) and PCa by means of Western blot analysis and immunofluorescence. The elevation of AR-A, and -B, as well as the AR-A/B ratio with regard to Gleason scores, were assessed in prostate cancer compared to BPH and normal prostate. In order to further investigate the role of AR A/B isoform function, we transfected PC3 cells with an AR or AR-A expression vector. The overexpression of AR-A and -B significantly decreased the invasion and proliferation of PC3 cells. However, the overexpression of AR-A further decreased proliferation but accelerated the invasion of PC3 cells compared to AR-B. In conclusion, the elevation of AR-A and -B, and the AR-A/B ratio, is associated with prostate cancer occurrence and progression. Furthermore, AR-A could provide a new potential therapy with regard to the decrease in the invasion and proliferation of prostate cancer cells. Our study provides insight into further understanding the biological role of AR-A in its interaction with AR-B and its impact on PCa clinical treatment.

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February 2012
Volume 27 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zeng R, Liu Z, Sun Y and Xu C: Differential expression and function of AR isoforms in prostate cancer. Oncol Rep 27: 492-498, 2012.
APA
Zeng, R., Liu, Z., Sun, Y., & Xu, C. (2012). Differential expression and function of AR isoforms in prostate cancer. Oncology Reports, 27, 492-498. https://doi.org/10.3892/or.2011.1516
MLA
Zeng, R., Liu, Z., Sun, Y., Xu, C."Differential expression and function of AR isoforms in prostate cancer". Oncology Reports 27.2 (2012): 492-498.
Chicago
Zeng, R., Liu, Z., Sun, Y., Xu, C."Differential expression and function of AR isoforms in prostate cancer". Oncology Reports 27, no. 2 (2012): 492-498. https://doi.org/10.3892/or.2011.1516