Overexpression of heparanase in ovarian cancer and its clinical significance

  • Authors:
    • Wei Zhang
    • Hong Chan
    • Louwei Wei
    • Zhongmian Pan
    • Jieqing Zhang
    • Li Li
  • View Affiliations

  • Published online on: August 27, 2013     https://doi.org/10.3892/or.2013.2701
  • Pages: 2279-2287
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Abstract

It has been reported that heparanase (HPSE) is overexpressed in ovarian cancer and is associated with tumor invasion and metastasis. However, a systematic study on the contribution of HPSE to tumor metastasis is rarely reported. In this study, based on the measurement of HPSE serum concentration, the expression of HPSE at both the mRNA and protein levels in tumors and its effects on the biological behaviors of cancer cells, we elucidated the role of HPSE in tumor invasion and metastasis in ovarian cancer and concluded that either the expression of HPSE in cancer and/or the serum concentration of HPSE may be a useful biomarker for the evaluation of surgery effects and prognosis prediction.
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November 2013
Volume 30 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang W, Chan H, Wei L, Pan Z, Zhang J and Li L: Overexpression of heparanase in ovarian cancer and its clinical significance. Oncol Rep 30: 2279-2287, 2013
APA
Zhang, W., Chan, H., Wei, L., Pan, Z., Zhang, J., & Li, L. (2013). Overexpression of heparanase in ovarian cancer and its clinical significance. Oncology Reports, 30, 2279-2287. https://doi.org/10.3892/or.2013.2701
MLA
Zhang, W., Chan, H., Wei, L., Pan, Z., Zhang, J., Li, L."Overexpression of heparanase in ovarian cancer and its clinical significance". Oncology Reports 30.5 (2013): 2279-2287.
Chicago
Zhang, W., Chan, H., Wei, L., Pan, Z., Zhang, J., Li, L."Overexpression of heparanase in ovarian cancer and its clinical significance". Oncology Reports 30, no. 5 (2013): 2279-2287. https://doi.org/10.3892/or.2013.2701