FTY720 for cancer therapy (Review)

  • Authors:
    • Li Zhang
    • Han-Dong Wang
    • Xiang-Jun Ji
    • Zi-Xiang Cong
    • Jian-Hong Zhu
    • Yuan Zhou
  • View Affiliations

  • Published online on: October 1, 2013     https://doi.org/10.3892/or.2013.2765
  • Pages: 2571-2578
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Abstract

2-Amino-2-[2-(4-octylphenyl)]-1,3-propanediol hydrochloride (FTY720) is a potent immunosuppressant which has been approved by the Food and Drug Administration (FDA) as a new treatment for multiple sclerosis. As an immunosuppressant, it displays its anti-multiple sclerosis, immunosuppressive effects by activating sphingosine-1-phosphate receptors (S1PRs). In addition to the immunosuppressive effects, FTY720 also shows preclinical antitumor efficacy in several cancer models. In most cases, phosphorylation of FTY720 is not required for its cytotoxic effect, indicating the involvement of S1PR-independent mechanisms which are starkly different from the immunosuppressive property of FTY720. In the present study, we reviewed the rapidly advancing field of FTY720 in cancer therapy as well as some molecular targets of the unphosphorylated form of FTY720.
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December 2013
Volume 30 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang L, Wang H, Ji X, Cong Z, Zhu J and Zhou Y: FTY720 for cancer therapy (Review). Oncol Rep 30: 2571-2578, 2013.
APA
Zhang, L., Wang, H., Ji, X., Cong, Z., Zhu, J., & Zhou, Y. (2013). FTY720 for cancer therapy (Review). Oncology Reports, 30, 2571-2578. https://doi.org/10.3892/or.2013.2765
MLA
Zhang, L., Wang, H., Ji, X., Cong, Z., Zhu, J., Zhou, Y."FTY720 for cancer therapy (Review)". Oncology Reports 30.6 (2013): 2571-2578.
Chicago
Zhang, L., Wang, H., Ji, X., Cong, Z., Zhu, J., Zhou, Y."FTY720 for cancer therapy (Review)". Oncology Reports 30, no. 6 (2013): 2571-2578. https://doi.org/10.3892/or.2013.2765