Wnt1 inducible signalling pathway protein-2 (WISP‑2/CCN5): Roles and regulation in human cancers (Review)

  • Authors:
    • Jiafu Ji
    • Shuqin Jia
    • Ke Ji
    • Wen G. Jiang
  • View Affiliations

  • Published online on: December 9, 2013     https://doi.org/10.3892/or.2013.2909
  • Pages: 533-539
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Abstract

Wnt1 inducible signalling pathway protein-2 (WISP‑2), also known as CCN5, CT58, CTGF-L, CTGF-3, HICP and Cop1, is one of the 3 WNT1 inducible proteins that belongs to the CCN family. This family of members has been shown to play multiple roles in a number of pathophysiological processes, including cell proliferation, adhesion, wound healing, extracellular matrix regulation, epithelial-mesenchymal transition, angiogenesis, fibrosis, skeletal development and embryo implantation. Recent results suggest that WISP-2 is relevant to tumorigenesis and malignant transformation, particularly in breast cancer, colorectal cancer and hepatocarcinoma. Notably, its roles in cancer appear to vary depending on cell/tumour type and the microenvironment. The striking difference in the structure of WISP-2 in comparison with the other 2 family members may contribute to its difference in functions, which leads to the hypothesis that WISP-2 may act as a dominant-negative regulator of other CCN family members. In the present review, we summarise the roles, regulation and underlying mechanism of WISP-2 in human cancers.
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2014-February
Volume 31 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ji J, Jia S, Ji K and Jiang WG: Wnt1 inducible signalling pathway protein-2 (WISP‑2/CCN5): Roles and regulation in human cancers (Review). Oncol Rep 31: 533-539, 2014.
APA
Ji, J., Jia, S., Ji, K., & Jiang, W.G. (2014). Wnt1 inducible signalling pathway protein-2 (WISP‑2/CCN5): Roles and regulation in human cancers (Review). Oncology Reports, 31, 533-539. https://doi.org/10.3892/or.2013.2909
MLA
Ji, J., Jia, S., Ji, K., Jiang, W. G."Wnt1 inducible signalling pathway protein-2 (WISP‑2/CCN5): Roles and regulation in human cancers (Review)". Oncology Reports 31.2 (2014): 533-539.
Chicago
Ji, J., Jia, S., Ji, K., Jiang, W. G."Wnt1 inducible signalling pathway protein-2 (WISP‑2/CCN5): Roles and regulation in human cancers (Review)". Oncology Reports 31, no. 2 (2014): 533-539. https://doi.org/10.3892/or.2013.2909