Open Access

Feasibility of concervative breast surgery and intraoperative radiation therapy for early breast cancer: A single-center, open, non-randomized, prospective pilot study

  • Authors:
    • Carla Cedolini
    • Serena Bertozzi
    • Luca Seriau
    • Ambrogio P. Londero
    • Serena Concina
    • Eugenia Moretti
    • Renato Padovani
    • Alberto Pasqualucci
    • Tino Ceschia
    • Andrea Risaliti
  • View Affiliations

  • Published online on: February 11, 2014     https://doi.org/10.3892/or.2014.3018
  • Pages: 1539-1546
  • Copyright: © Cedolini et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Intraoperative radiotherapy (IORT) consists of an accelerated, single-dose, partial breast irradiation, performed immediately after breast conservative surgery. In the present study, we report the results of our feasibility protocol study using IORT between 2005 and 2009. We analyzed the data from a single-center, open, non-randomized, prospective pilot study including patients who underwent breast conservative surgery for invasive breast cancer between January 2005 and December 2009 at our Clinic of Surgery. Patients were divided based on IORT performance and stratified by age (≥48 or <48 years). Data were analyzed using R (version 2.15.2), considering a level of significance at p<0.05. Among the 247 eligible patients, 81 accepted the IORT protocol. Intraoperative IORT feasibility was 95.1% (77/81). In 71.4% (55/77) of the cases no postoperative complication was registered. Concerning local recurrence and overall survival, no significant difference was observed between women who underwent the IORT protocol or standard treatment. Among the patients aged <48 years, no local recurrence was noted after IORT protocol, and among women aged ≥48, local recurrences developed later in patients treated with IORT than with standard treatment. IORT represents a feasible and promising technique for the treatment of early breast cancer, with low morbidity, and beneficial aesthetic and oncologic results. Further studies are required in order to extend the inclusion criteria and offer IORT to a larger number of breast cancer patients.
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2014-April
Volume 31 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Cedolini C, Bertozzi S, Seriau L, Londero AP, Concina S, Moretti E, Padovani R, Pasqualucci A, Ceschia T, Risaliti A, Risaliti A, et al: Feasibility of concervative breast surgery and intraoperative radiation therapy for early breast cancer: A single-center, open, non-randomized, prospective pilot study. Oncol Rep 31: 1539-1546, 2014.
APA
Cedolini, C., Bertozzi, S., Seriau, L., Londero, A.P., Concina, S., Moretti, E. ... Risaliti, A. (2014). Feasibility of concervative breast surgery and intraoperative radiation therapy for early breast cancer: A single-center, open, non-randomized, prospective pilot study. Oncology Reports, 31, 1539-1546. https://doi.org/10.3892/or.2014.3018
MLA
Cedolini, C., Bertozzi, S., Seriau, L., Londero, A. P., Concina, S., Moretti, E., Padovani, R., Pasqualucci, A., Ceschia, T., Risaliti, A."Feasibility of concervative breast surgery and intraoperative radiation therapy for early breast cancer: A single-center, open, non-randomized, prospective pilot study". Oncology Reports 31.4 (2014): 1539-1546.
Chicago
Cedolini, C., Bertozzi, S., Seriau, L., Londero, A. P., Concina, S., Moretti, E., Padovani, R., Pasqualucci, A., Ceschia, T., Risaliti, A."Feasibility of concervative breast surgery and intraoperative radiation therapy for early breast cancer: A single-center, open, non-randomized, prospective pilot study". Oncology Reports 31, no. 4 (2014): 1539-1546. https://doi.org/10.3892/or.2014.3018