Efficacy of dual-functional liposomes containing paclitaxel for treatment of lung cancer

Retraction in: /10.3892/or.2017.6006

  • Authors:
    • Rong-Hua Wang
    • Hong-Mei Cao
    • Zhi-Ju Tian
    • Bo Jin
    • Qing Wang
    • Hong Ma
    • Jing Wu
  • View Affiliations

  • Published online on: December 2, 2014     https://doi.org/10.3892/or.2014.3644
  • Pages: 783-791
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Abstract

This study was mainly focused on the development of a dual-ligand liposomal delivery system for targeting the delivery of paclitaxel (PTX) to lung cancer. The specific ligand peptide HAIYPRH (T7) and the cationic cell-penetrating peptide TAT were connected with phospholipid via a polyethylene glycol (PEG) spacer to prepare the dual-ligand liposomes (T7/TAT-LP-PTX). Physicochemical characterizations of T7/TAT-LP-PTX, such as particle size, ζ potential, morphology, encapsulation efficiency, and in vitro PTX release, were also evaluated. In the cellular uptake study, the T7/TAT-LP endocytosed by the A549 cells was 2.26‑, 3.48‑ and 8.56‑fold higher than TAT-LP, T7-LP and LP, respectively. The IC50 values of TAT-LP-PTX, T7-LP-PTX and LP-PTX were much higher than those of T7/TAT-LP-PTX, respectively. The homing specificity of T7/TAT-LP was evaluated on the tumor spheroids, which revealed that T7/TAT-LP was more efficaciously internalized in tumor cells than TAT-LP, T7-LP and LP, respectively. Compared to LP, TAT-LP and T7-LP, T7/TAT-LP showed the strongest cell uptake property, and the highest accumulation ability in tumor spheroids in vitro. In the in vivo study, the T7/TAT-LP-PTX exhibited the best inhibitory effect of tumor growth for A549-bearing mice. Collectively, these results suggested that T7/TAT-LP-PTX is a promising drug delivery system for the treatment of lung cancer.
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February-2015
Volume 33 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wang R, Cao H, Tian Z, Jin B, Wang Q, Ma H and Wu J: Efficacy of dual-functional liposomes containing paclitaxel for treatment of lung cancer Retraction in /10.3892/or.2017.6006. Oncol Rep 33: 783-791, 2015.
APA
Wang, R., Cao, H., Tian, Z., Jin, B., Wang, Q., Ma, H., & Wu, J. (2015). Efficacy of dual-functional liposomes containing paclitaxel for treatment of lung cancer Retraction in /10.3892/or.2017.6006. Oncology Reports, 33, 783-791. https://doi.org/10.3892/or.2014.3644
MLA
Wang, R., Cao, H., Tian, Z., Jin, B., Wang, Q., Ma, H., Wu, J."Efficacy of dual-functional liposomes containing paclitaxel for treatment of lung cancer Retraction in /10.3892/or.2017.6006". Oncology Reports 33.2 (2015): 783-791.
Chicago
Wang, R., Cao, H., Tian, Z., Jin, B., Wang, Q., Ma, H., Wu, J."Efficacy of dual-functional liposomes containing paclitaxel for treatment of lung cancer Retraction in /10.3892/or.2017.6006". Oncology Reports 33, no. 2 (2015): 783-791. https://doi.org/10.3892/or.2014.3644