IκB kinase α functions as a tumor suppressor in epithelial-derived tumors through an NF-κB-independent pathway (Review)

  • Authors:
    • Yuxin Xie
    • Keqi Xie
    • Qiheng Gou
    • Nianyong Chen
  • View Affiliations

  • Published online on: August 26, 2015     https://doi.org/10.3892/or.2015.4229
  • Pages: 2225-2232
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Recent studies have shown that IκB kinase α (IKKα) plays an important role in human skin cancer and acts as a major regulator for keratinocyte terminal differentiation and proliferation. IKKα deficiency or mutation is associated with human tumor development; thus, overexpression of IKKα could prevent tumor progression. However, findings suggest that IKKα is equally essential for many other epithelial-derived tumors. In the present study, we discussed the role of IKKα as a tumor suppressor in IKKα-mediated epithelial‑derived tumors and its activation pathway, which is different from the traditional NF-κB pathway. The present study provides theoretical basis for understanding the molecular mechanisms involved in IKKα-related tumors.
View Figures
View References

Related Articles

Journal Cover

November-2015
Volume 34 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xie Y, Xie K, Gou Q and Chen N: IκB kinase α functions as a tumor suppressor in epithelial-derived tumors through an NF-κB-independent pathway (Review). Oncol Rep 34: 2225-2232, 2015.
APA
Xie, Y., Xie, K., Gou, Q., & Chen, N. (2015). IκB kinase α functions as a tumor suppressor in epithelial-derived tumors through an NF-κB-independent pathway (Review). Oncology Reports, 34, 2225-2232. https://doi.org/10.3892/or.2015.4229
MLA
Xie, Y., Xie, K., Gou, Q., Chen, N."IκB kinase α functions as a tumor suppressor in epithelial-derived tumors through an NF-κB-independent pathway (Review)". Oncology Reports 34.5 (2015): 2225-2232.
Chicago
Xie, Y., Xie, K., Gou, Q., Chen, N."IκB kinase α functions as a tumor suppressor in epithelial-derived tumors through an NF-κB-independent pathway (Review)". Oncology Reports 34, no. 5 (2015): 2225-2232. https://doi.org/10.3892/or.2015.4229