131I therapy mediated by sodium/iodide symporter combined with kringle 5 has a synergistic therapeutic effect on glioma

  • Authors:
    • Shuo Shi
    • Min Zhang
    • Rui Guo
    • Miao Zhang
    • Jiajia Hu
    • Yun Xi
    • Ying Miao
    • Biao Li
  • View Affiliations

  • Published online on: November 13, 2015     https://doi.org/10.3892/or.2015.4420
  • Pages: 691-698
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Glioblastoma (GBM) is the most common and most aggressive primary brain tumor; the prognosis of patients with GBM remains poor. The sodium/iodide symporter (NIS) can be used to absorb several isotopes, such as 131I for nuclear medicine imaging and radionuclide therapy. Previously, we found that the early growth response-1 (Egr1) promoter had an 131I radiation positive feedback effect on the NIS gene. Kringle 5 (K5), a kringle domain of plasminogen, induced endothelial cell apoptosis. We investigated the effect of K5 combined with the 131I radiation positive feedback effect (Egr1-NIS) for treating malignant U87 glioma cells using a lentiviral vector. We successfully constructed a stable U87 glioma cell line, U87-K5-Egr1-NIS. The radio-inducible Egr1 promoter induced an 131I radiation positive feedback effect absorbed by NIS. Mediated by 131I, K5 increased glioma cell apoptosis; 131I radiation also increased endothelial cell sensitivity to K5-induced apoptosis. The combined therapy had a synergistic effect on the antitumor efficacy of glioma treatment, not only increasing tumor cell apoptosis but also significantly inhibiting tumor cell proliferation and reducing capillary density in U87 glioma tissues.
View Figures
View References

Related Articles

Journal Cover

February-2016
Volume 35 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Shi S, Zhang M, Guo R, Zhang M, Hu J, Xi Y, Miao Y and Li B: 131I therapy mediated by sodium/iodide symporter combined with kringle 5 has a synergistic therapeutic effect on glioma. Oncol Rep 35: 691-698, 2016
APA
Shi, S., Zhang, M., Guo, R., Zhang, M., Hu, J., Xi, Y. ... Li, B. (2016). 131I therapy mediated by sodium/iodide symporter combined with kringle 5 has a synergistic therapeutic effect on glioma. Oncology Reports, 35, 691-698. https://doi.org/10.3892/or.2015.4420
MLA
Shi, S., Zhang, M., Guo, R., Zhang, M., Hu, J., Xi, Y., Miao, Y., Li, B."131I therapy mediated by sodium/iodide symporter combined with kringle 5 has a synergistic therapeutic effect on glioma". Oncology Reports 35.2 (2016): 691-698.
Chicago
Shi, S., Zhang, M., Guo, R., Zhang, M., Hu, J., Xi, Y., Miao, Y., Li, B."131I therapy mediated by sodium/iodide symporter combined with kringle 5 has a synergistic therapeutic effect on glioma". Oncology Reports 35, no. 2 (2016): 691-698. https://doi.org/10.3892/or.2015.4420