Open Access

Chemically induced skin carcinogenesis: Updates in experimental models (Review)

  • Authors:
    • Monica Neagu
    • Constantin Caruntu
    • Carolina Constantin
    • Daniel Boda
    • Sabina Zurac
    • Demetrios A. Spandidos
    • Aristidis M. Tsatsakis
  • View Affiliations

  • Published online on: March 17, 2016     https://doi.org/10.3892/or.2016.4683
  • Pages: 2516-2528
  • Copyright: © Neagu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Skin cancer is one of the most common malignancies affecting humans worldwide, and its incidence is rapidly increasing. The study of skin carcinogenesis is of major interest for both scientific research and clinical practice and the use of in vivo systems may facilitate the investigation of early alterations in the skin and of the mechanisms involved, and may also lead to the development of novel therapeutic strategies for skin cancer. This review outlines several aspects regarding the skin toxicity testing domain in mouse models of chemically induced skin carcinogenesis. There are important strain differences in view of the histological type, development and clinical evolution of the skin tumor, differences reported decades ago and confirmed by our hands‑on experience. Using mouse models in preclinical testing is important due to the fact that, at the molecular level, common mechanisms with human cutaneous tumorigenesis are depicted. These animal models resemble human skin cancer development, in that genetic changes caused by carcinogens and pro‑inflammatory cytokines, and simultaneous inflammation sustained by pro‑inflammatory cytokines and chemokines favor tumor progression. Drugs and environmental conditions can be tested using these animal models. keeping in mind the differences between human and rodent skin physiology.
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May-2016
Volume 35 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Neagu M, Caruntu C, Constantin C, Boda D, Zurac S, Spandidos DA and Tsatsakis AM: Chemically induced skin carcinogenesis: Updates in experimental models (Review). Oncol Rep 35: 2516-2528, 2016.
APA
Neagu, M., Caruntu, C., Constantin, C., Boda, D., Zurac, S., Spandidos, D.A., & Tsatsakis, A.M. (2016). Chemically induced skin carcinogenesis: Updates in experimental models (Review). Oncology Reports, 35, 2516-2528. https://doi.org/10.3892/or.2016.4683
MLA
Neagu, M., Caruntu, C., Constantin, C., Boda, D., Zurac, S., Spandidos, D. A., Tsatsakis, A. M."Chemically induced skin carcinogenesis: Updates in experimental models (Review)". Oncology Reports 35.5 (2016): 2516-2528.
Chicago
Neagu, M., Caruntu, C., Constantin, C., Boda, D., Zurac, S., Spandidos, D. A., Tsatsakis, A. M."Chemically induced skin carcinogenesis: Updates in experimental models (Review)". Oncology Reports 35, no. 5 (2016): 2516-2528. https://doi.org/10.3892/or.2016.4683