Depression accelerates the development of gastric cancer through reactive oxygen species‑activated ABL1 (Review)

  • Authors:
    • Tianhe Huang
    • Fuling Zhou
    • Feng Wang‑Johanning
    • Kejun Nan
    • Yongchang Wei
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  • Published online on: September 23, 2016     https://doi.org/10.3892/or.2016.5127
  • Pages: 2435-2443
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Abstract

Depression is a common symptom among gastric cancer (GC) patients and serves as a potential indication of poor prognosis and advanced cancer clinical stage. However, the molecular mechanism of depression‑associated poor prognoses of GC patients remains unclear. Recent studies have revealed that GC patients with depression are under high levels of oxidative stress (OS) status that is accompanied by the dysfunction of numerous proto‑oncogenes, including the ABL proto‑oncogene 1 (ABL1), which is a non‑receptor tyrosine kinase. Recent evidence indicates that ABL1 was dysregulated in both major depressive disorder (MDD) and cancer patients with depression, and high levels of reactive oxygen species (ROS) can lead to the activation of ABL1 in response to OS and that activated ABL1 subsequently contributes to development of GC via interactions with the downstream targets and corresponding signaling pathways. In this review, we examine the evidence to illuminate the molecular mechanism of ABL1 in the progression of GC patients with depression and identify out new and effective methods for the initial and long‑term treatment of GC.
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November-2016
Volume 36 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Huang T, Zhou F, Wang‑Johanning F, Nan K and Wei Y: Depression accelerates the development of gastric cancer through reactive oxygen species‑activated ABL1 (Review). Oncol Rep 36: 2435-2443, 2016.
APA
Huang, T., Zhou, F., Wang‑Johanning, F., Nan, K., & Wei, Y. (2016). Depression accelerates the development of gastric cancer through reactive oxygen species‑activated ABL1 (Review). Oncology Reports, 36, 2435-2443. https://doi.org/10.3892/or.2016.5127
MLA
Huang, T., Zhou, F., Wang‑Johanning, F., Nan, K., Wei, Y."Depression accelerates the development of gastric cancer through reactive oxygen species‑activated ABL1 (Review)". Oncology Reports 36.5 (2016): 2435-2443.
Chicago
Huang, T., Zhou, F., Wang‑Johanning, F., Nan, K., Wei, Y."Depression accelerates the development of gastric cancer through reactive oxygen species‑activated ABL1 (Review)". Oncology Reports 36, no. 5 (2016): 2435-2443. https://doi.org/10.3892/or.2016.5127