1
|
El-Serag HB and Rudolph KL: Hepatocellular
carcinoma: Epidemiology and molecular carcinogenesis.
Gastroenterology. 132:2557–2576. 2007. View Article : Google Scholar : PubMed/NCBI
|
2
|
Hu Z, Zhou Z, Xiong G, Wang Y, Lai Y, Deng
L and Yang J: Cyclin D1 G870A polymorphism and the risk of
hepatocellular carcinoma in a Chinese population. Tumour Biol.
35:5607–5612. 2014. View Article : Google Scholar : PubMed/NCBI
|
3
|
Berasain C, Castillo J, Prieto J and Avila
MA: New molecular targets for hepatocellular carcinoma: The ErbB1
signaling system. Liver Int. 27:174–185. 2007. View Article : Google Scholar : PubMed/NCBI
|
4
|
Gan FY, Gesell MS, Alousi M and Luk GD:
Analysis of ODC and c-myc gene expression in hepatocellular
carcinoma by in situ hybridization and immunohistochemistry. J
Histochem Cytochem. 41:1185–1196. 1993. View Article : Google Scholar : PubMed/NCBI
|
5
|
Newell P, Toffanin S, Villanueva A, Chiang
DY, Minguez B, Cabellos L, Savic R, Hoshida Y, Lim KH,
Melgar-Lesmes P, et al: Ras pathway activation in hepatocellular
carcinoma and anti-tumoral effect of combined sorafenib and
rapamycin in vivo. J Hepatol. 51:725–733. 2009. View Article : Google Scholar : PubMed/NCBI
|
6
|
Edgar R, Domrachev M and Lash AE: Gene
Expression Omnibus: NCBI gene expression and hybridization array
data repository. Nucleic Acids Res. 30:207–210. 2002. View Article : Google Scholar : PubMed/NCBI
|
7
|
Elgaaen BV, Olstad OK, Sandvik L, Odegaard
E, Sauer T, Staff AC and Gautvik KM: ZNF385B and VEGFA are strongly
differentially expressed in serous ovarian carcinomas and correlate
with survival. PLoS One. 7:e463172012. View Article : Google Scholar : PubMed/NCBI
|
8
|
Mok SC, Bonome T, Vathipadiekal V, Bell A,
Johnson ME, Wong KK, Park DC, Hao K, Yip DK, Donninger H, et al: A
gene signature predictive for outcome in advanced ovarian cancer
identifies a survival factor: Microfibril-associated glycoprotein
2. Cancer Cell. 16:521–532. 2009. View Article : Google Scholar : PubMed/NCBI
|
9
|
Bowen NJ, Walker LD, Matyunina LV, Logani
S, Totten KA, Benigno BB and McDonald JF: Gene expression profiling
supports the hypothesis that human ovarian surface epithelia are
multipotent and capable of serving as ovarian cancer initiating
cells. BMC Med Genomics. 2:712009. View Article : Google Scholar : PubMed/NCBI
|
10
|
Huang DW, Sherman BT, Tan Q, Collins JR,
Alvord WG, Roayaei J, Stephens R, Baseler MW, Lane HC and Lempicki
RA: The DAVID Gene Functional Classification Tool: A novel
biological module-centric algorithm to functionally analyze large
gene lists. Genome Biol. 8:R1832007. View Article : Google Scholar : PubMed/NCBI
|
11
|
Kanehisa M: The KEGG database. Novartis
Found Symp. 247:91–252. 2002. View Article : Google Scholar : PubMed/NCBI
|
12
|
Ashburner M, Ball CA, Blake JA, Botstein
D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT,
et al: Gene ontology: Tool for the unification of biology. The Gene
Ontology Consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI
|
13
|
Franceschini A, Szklarczyk D, Frankild S,
Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering
C, et al: STRING v9.1: Protein-protein interaction networks, with
increased coverage and integration. Nucleic Acids Res.
41:D808–D815. 2013. View Article : Google Scholar : PubMed/NCBI
|
14
|
Smoot ME, Ono K, Ruscheinski J, Wang PL
and Ideker T: Cytoscape 2.8: New features for data integration and
network visualization. Bioinformatics. 27:431–432. 2011. View Article : Google Scholar : PubMed/NCBI
|
15
|
Bandettini WP, Kellman P, Mancini C,
Booker OJ, Vasu S, Leung SW, Wilson JR, Shanbhag SM, Chen MY and
Arai AE: MultiContrast Delayed Enhancement (MCODE) improves
detection of subendocardial myocardial infarction by late
gadolinium enhancement cardiovascular magnetic resonance: A
clinical validation study. J Cardiovasc Magn Reson. 14:832012.
View Article : Google Scholar : PubMed/NCBI
|
16
|
Gao J, Aksoy BA, Dogrusoz U, Dresdner G,
Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al:
Integrative analysis of complex cancer genomics and clinical
profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI
|
17
|
Cerami E, Gao J, Dogrusoz U, Gross BE,
Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et
al: The cBio cancer genomics portal: An open platform for exploring
multidimensional cancer genomics data. Cancer Discov. 2:401–404.
2012. View Article : Google Scholar : PubMed/NCBI
|
18
|
Maere S, Heymans K and Kuiper M: BiNGO: A
Cytoscape plugin to assess overrepresentation of gene ontology
categories in biological networks. Bioinformatics. 21:3448–3449.
2005. View Article : Google Scholar : PubMed/NCBI
|
19
|
Kent WJ, Sugnet CW, Furey TS, Roskin KM,
Pringle TH, Zahler AM and Haussler D: The human genome browser at
UCSC. Genome Res. 12:996–1006. 2002. View Article : Google Scholar : PubMed/NCBI
|
20
|
Chen X, Cheung ST, So S, Fan ST, Barry C,
Higgins J, Lai KM, Ji J, Dudoit S, Ng IO, et al: Gene expression
patterns in human liver cancers. Mol Biol Cell. 13:1929–1939. 2002.
View Article : Google Scholar : PubMed/NCBI
|
21
|
Roessler S, Jia HL, Budhu A, Forgues M, Ye
QH, Lee JS, Thorgeirsson SS, Sun Z, Tang ZY, Qin LX, et al: A
unique metastasis gene signature enables prediction of tumor
relapse in early-stage hepatocellular carcinoma patients. Cancer
Res. 70:10202–10212. 2010. View Article : Google Scholar : PubMed/NCBI
|
22
|
Wurmbach E, Chen YB, Khitrov G, Zhang W,
Roayaie S, Schwartz M, Fiel I, Thung S, Mazzaferro V, Bruix J, et
al: Genome-wide molecular profiles of HCV-induced dysplasia and
hepatocellular carcinoma. Hepatology. 45:938–947. 2007. View Article : Google Scholar : PubMed/NCBI
|
23
|
Turner PC, Sylla A, Diallo MS, Castegnaro
JJ, Hall AJ and Wild CP: The role of aflatoxins and hepatitis
viruses in the etiopathogenesis of hepatocellular carcinoma: A
basis for primary prevention in Guinea-Conakry, West Africa. J
Gastroenterol Hepatol. 17 Suppl:S441–S448. 2002. View Article : Google Scholar : PubMed/NCBI
|
24
|
Wang Y, Cheng J, Xu C, Liu S, Jiang S, Xu
Q, Chen X, Zhuang H and Lu F: Quantitative methylation analysis
reveals gender and age differences in p16INK4a hypermethylation in
hepatitis B virus-related hepatocellular carcinoma. Liver Int.
32:420–428. 2012.PubMed/NCBI
|
25
|
Choi YL, Park SH, Jang JJ and Park CK:
Expression of the G1-S modulators in hepatitis B virus-related
hepatocellular carcinoma and dysplastic nodule: Association of
cyclin D1 and p53 proteins with the progression of hepatocellular
carcinoma. J Korean Med Sci. 16:424–432. 2001. View Article : Google Scholar : PubMed/NCBI
|
26
|
Snider NT, Altshuler PJ, Wan S, Welling
TH, Cavalcoli J and Omary MB: Alternative splicing of human NT5E in
cirrhosis and hepatocellular carcinoma produces a negative
regulator of ecto-5-nucleotidase (CD73). Mol Biol Cell.
25:4024–4033. 2014. View Article : Google Scholar : PubMed/NCBI
|
27
|
Gill RBS, Day A, Barstow A, Zaman G, Chenu
C and Dhoot GK: Mammalian Sulf1 RNA alternative splicing and its
significance to tumour growth regulation. Tumour Biol.
33:1669–1680. 2012. View Article : Google Scholar : PubMed/NCBI
|
28
|
Franklin RB, Levy BA, Zou J, Hanna N,
Desouki MM, Bagasra O, Johnson LA and Costello LC: ZIP14 zinc
transporter downregulation and zinc depletion in the development
and progression of hepatocellular cancer. J Gastrointest Cancer.
43:249–257. 2012. View Article : Google Scholar : PubMed/NCBI
|
29
|
Tripathi V, Shen Z, Chakraborty A, Giri S,
Freier SM, Wu X, Zhang Y, Gorospe M, Prasanth SG, Lal A, et al:
Long noncoding RNA MALAT1 controls cell cycle progression by
regulating the expression of oncogenic transcription factor B-MYB.
PLoS Genet. 9:e10033682013. View Article : Google Scholar : PubMed/NCBI
|
30
|
Markiewski MM and Lambris JD: Unwelcome
complement. Cancer Res. 69:6367–6370. 2009. View Article : Google Scholar : PubMed/NCBI
|
31
|
Abu-Remaileh M and Aqeilan RI: The tumor
suppressor WW domain-containing oxidoreductase modulates cell
metabolism. Exp Biol Med. 240:345–350. 2015. View Article : Google Scholar
|
32
|
Roszczenko P, Radomska KA, Wywial E,
Collet JF and Jagusztyn-Krynicka EK: A novel insight into the
oxidoreductase activity of Helicobacter pylori HP0231 protein. PLoS
One. 7:e465632012. View Article : Google Scholar : PubMed/NCBI
|
33
|
Watanuki A, Ohwada S, Fukusato T, Makita
F, Yamada T, Kikuchi A and Morishita Y: Prognostic significance of
DNA topoisomerase IIalpha expression in human hepatocellular
carcinoma. Anticancer Res. 22:1113–1119. 2002.PubMed/NCBI
|
34
|
Nakajima T, Yasui K, Zen K, Inagaki Y,
Fujii H, Minami M, Tanaka S, Taniwaki M, Itoh Y, Arii S, et al:
Activation of B-Myb by E2F1 in hepatocellular carcinoma. Hepatol
Res. 38:886–895. 2008.PubMed/NCBI
|
35
|
Chan HH, Chu TH, Chien HF, Sun CK, Wang
EM, Pan HB, Kuo HM, Hu TH, Lai KH, Cheng JT, et al: Rapid induction
of orthotopic hepatocellular carcinoma in immune-competent rats by
non-invasive ultrasound-guided cells implantation. BMC
Gastroenterol. 10:832010. View Article : Google Scholar : PubMed/NCBI
|
36
|
Wang N, Zhu M, Tsao SW, Man K, Zhang Z and
Feng Y: MiR-23a-mediated inhibition of topoisomerase 1 expression
potentiates cell response to etoposide in human hepatocellular
carcinoma. Mol Cancer. 12:1192013. View Article : Google Scholar : PubMed/NCBI
|
37
|
Wong N, Yeo W, Wong WL, Wong NL, Chan KY,
Mo FK, Koh J, Chan SL, Chan AT, Lai PB, et al: TOP2A overexpression
in hepatocellular carcinoma correlates with early age onset,
shorter patients survival and chemoresistance. Int J Cancer.
124:644–652. 2009. View Article : Google Scholar : PubMed/NCBI
|
38
|
Fritz P, Cabrera CM, Dippon J, Gerteis A,
Simon W, Aulitzky WE and van der Kuip H: c-erbB2 and topoisomerase
IIalpha protein expression independently predict poor survival in
primary human breast cancer: A retrospective study. Breast Cancer
Res. 7:R374–R384. 2005. View Article : Google Scholar : PubMed/NCBI
|
39
|
Panvichian R, Tantiwetrueangdet A,
Angkathunyakul N and Leelaudomlipi S: TOP2A amplification and
overexpression in hepatocellular carcinoma tissues. Biomed Res Int.
2015:3816022015. View Article : Google Scholar : PubMed/NCBI
|
40
|
Dingemans AM, Witlox MA, Stallaert RA, van
der Valk P, Postmus PE and Giaccone G: Expression of DNA
topoisomerase IIalpha and topoisomerase IIbeta genes predicts
survival and response to chemotherapy in patients with small cell
lung cancer. Clin Cancer Res. 5:2048–2058. 1999.PubMed/NCBI
|
41
|
Lazaris AC, Kavantzas NG, Zorzos HS,
Tsavaris NV and Davaris PS: Markers of drug resistance in relapsing
colon cancer. J Cancer Res Clin Oncol. 128:114–118. 2002.
View Article : Google Scholar : PubMed/NCBI
|
42
|
Costa MJ, Hansen CL, Holden JA and Guinee
D Jr: Topoisomerase II alpha: Prognostic predictor and cell cycle
marker in surface epithelial neoplasms of the ovary and peritoneum.
Int J Gynecol Pathol. 19:248–257. 2000. View Article : Google Scholar : PubMed/NCBI
|
43
|
Zhang Y, Huang W, Ran Y, Xiong Y, Zhong Z,
Fan X, Wang Z and Ye Q: miR-582-5p inhibits proliferation of
hepatocellular carcinoma by targeting CDK1 and AKT3. Tumour Biol.
36:8309–8316. 2015. View Article : Google Scholar : PubMed/NCBI
|
44
|
Zhao J, Han SX, Ma JL, Ying X, Liu P, Li
J, Wang L, Zhang Y, Ma J, Zhang L, et al: The role of CDK1 in
apoptin-induced apoptosis in hepatocellular carcinoma cells. Oncol
Rep. 30:253–259. 2013. View Article : Google Scholar : PubMed/NCBI
|
45
|
Guzman JR, Fukuda S and Pelus LM:
Inhibition of caspase-3 by Survivin prevents Wee1 Kinase
degradation and promotes cell survival by maintaining
phosphorylation of p34Cdc2. Gene Ther Mol Biol. 13B:1–273.
2009.
|
46
|
Terrano DT, Upreti M and Chambers TC:
Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2
phosphorylation acts as a functional link coupling mitotic arrest
and apoptosis. Mol Cell Biol. 30:640–656. 2010. View Article : Google Scholar : PubMed/NCBI
|
47
|
Jacquemet G, Green DM, Bridgewater RE, von
Kriegsheim A, Humphries MJ, Norman JC and Caswell PT: RCP-driven
α5β1 recycling suppresses Rac and promotes RhoA activity via the
RacGAP1-IQGAP1 complex. J Cell Biol. 202:917–935. 2013. View Article : Google Scholar : PubMed/NCBI
|
48
|
Bornschein J, Nielitz J, Drozdov I,
Selgrad M, Wex T, Jechorek D, Link A, Vieth M and Malfertheiner P:
Expression of aurora kinase A correlates with the Wnt-modulator
RACGAP1 in gastric cancer. Cancer Med. 5:516–526. 2016. View Article : Google Scholar : PubMed/NCBI
|
49
|
Subramanian R, Ti SC, Tan L, Darst SA and
Kapoor TM: Marking and measuring single microtubules by PRC1 and
kinesin-4. Cell. 154:377–390. 2013. View Article : Google Scholar : PubMed/NCBI
|
50
|
Chen J, Rajasekaran M, Xia H, Zhang X,
Kong SN, Sekar K, Seshachalam VP, Deivasigamani A, Goh BK, Ooi LL,
et al: The microtubule-associated protein PRC1 promotes early
recurrence of hepatocellular carcinoma in association with the
Wnt/β-catenin signalling pathway. Gut. 65:1522–1534. 2016.
View Article : Google Scholar : PubMed/NCBI
|
51
|
Li J, Gao JZ, Du JL, Huang ZX and Wei LX:
Increased CDC20 expression is associated with development and
progression of hepatocellular carcinoma. Int J Oncol. 45:1547–1555.
2014. View Article : Google Scholar : PubMed/NCBI
|
52
|
Deng LJ, Peng QL, Wang LH, Xu J, Liu JS,
Li YJ, Zhuo ZJ, Bai LL, Hu LP, Chen WM, et al: Arenobufagin
intercalates with DNA leading to G2 cell cycle arrest
via ATM/ATR pathway. Oncotarget. 6:34258–34275. 2015.PubMed/NCBI
|
53
|
Semaan A, Dietrich D, Bergheim D, Dietrich
J, Kalff JC, Branchi V, Matthaei H, Kristiansen G, Fischer HP and
Goltz D: CXCL12 expression and PD-L1 expression serve as prognostic
biomarkers in HCC and are induced by hypoxia. Virchows Arch.
470:185–196. 2017. View Article : Google Scholar : PubMed/NCBI
|
54
|
Wang J, Tang X, Weng W, Qiao Y, Lin J, Liu
W, Liu R, Ma L, Yu W, Yu Y, et al: The membrane protein melanoma
cell adhesion molecule (MCAM) is a novel tumor marker that
stimulates tumorigenesis in hepatocellular carcinoma. Oncogene.
34:5781–5795. 2015. View Article : Google Scholar : PubMed/NCBI
|
55
|
Zhu P, Jin J, Liao Y, Li J, Yu XZ, Liao W
and He S: A novel prognostic biomarker SPC24 up-regulated in
hepatocellular carcinoma. Oncotarget. 6:41383–41397. 2015.
View Article : Google Scholar : PubMed/NCBI
|
56
|
Shi C, Huang D, Lu N, Chen D, Zhang M, Yan
Y, Deng L, Lu Q, Lu H and Luo S: Aberrantly activated Gli2-KIF20A
axis is crucial for growth of hepatocellular carcinoma and predicts
poor prognosis. Oncotarget. 7:26206–26219. 2016. View Article : Google Scholar : PubMed/NCBI
|
57
|
Gordon CA, Gulzar ZG and Brooks JD: NUSAP1
expression is upregulated by loss of RB1 in prostate cancer cells.
Prostate. 75:517–526. 2015. View Article : Google Scholar : PubMed/NCBI
|
58
|
Jiang W, Wang Z, Chen G and Jia Y:
Prognostic significance of centrosomal protein 55 in stage I
pulmonary adenocarcinoma after radical resection. Thorac Cancer.
7:316–322. 2016. View Article : Google Scholar : PubMed/NCBI
|
59
|
Wang Y, Jin T, Dai X and Xu J:
Lentivirus-mediated knockdown of CEP55 suppresses cell
proliferation of breast cancer cells. Biosci Trends. 10:67–73.
2016. View Article : Google Scholar : PubMed/NCBI
|
60
|
Weinberger P, Ponny SR, Xu H, et al: Cell
cycle M-phase genes are highly upregulated in anaplastic thyroid
carcinoma. Thyroid. 27:236–252. 2017. View Article : Google Scholar : PubMed/NCBI
|
61
|
Wang Z, Katsaros D, Shen Y, Fu Y, Canuto
EM, Benedetto C, Lu L, Chu WM, Risch HA and Yu H: Biological and
clinical significance of MAD2L1 and BUB1, genes frequently
appearing in expression signatures for breast cancer prognosis.
PLoS One. 10:e01362462015. View Article : Google Scholar : PubMed/NCBI
|
62
|
Kawashima SA, Yamagishi Y, Honda T,
Ishiguro K and Watanabe Y: Phosphorylation of H2A by Bub1 prevents
chromosomal instability through localizing shugoshin. Science.
327:172–177. 2010. View Article : Google Scholar : PubMed/NCBI
|
63
|
London N and Biggins S: Mad1 kinetochore
recruitment by Mps1-mediated phosphorylation of Bub1 signals the
spindle checkpoint. Genes Dev. 28:140–152. 2014. View Article : Google Scholar : PubMed/NCBI
|
64
|
Takashima S, Saito H, Takahashi N, Imai K,
Kudo S, Atari M, Saito Y, Motoyama S and Minamiya Y: Strong
expression of cyclin B2 mRNA correlates with a poor prognosis in
patients with non-small cell lung cancer. Tumour Biol.
35:4257–4265. 2014. View Article : Google Scholar : PubMed/NCBI
|
65
|
Lei CY, Wang W, Zhu YT, Fang WY and Tan
WL: The decrease of cyclin B2 expression inhibits invasion and
metastasis of bladder cancer. Urol Oncol. 34:237.e1–237.e10. 2016.
View Article : Google Scholar
|
66
|
Zhao F, Siu MK, Jiang L, Tam KF, Ngan HY,
Le XF, Wong OG, Wong ES, Gomes AR, Bella L, et al: Overexpression
of forkhead box protein M1 (FOXM1) in ovarian cancer correlates
with poor patient survival and contributes to paclitaxel
resistance. PLoS One. 9:e1134782014. View Article : Google Scholar : PubMed/NCBI
|
67
|
Shimo A, Tanikawa C, Nishidate T, Lin ML,
Matsuda K, Park JH, Ueki T, Ohta T, Hirata K, Fukuda M, et al:
Involvement of kinesin family member 2C/mitotic
centromere-associated kinesin overexpression in mammary
carcinogenesis. Cancer Sci. 99:62–70. 2008.PubMed/NCBI
|