Resveratrol epigenetically regulates the expression of zinc finger protein 36 in non‑small cell lung cancer cell lines

  • Authors:
    • Ahmad Fudhaili
    • Nal Ae Yoon
    • Seokmin Kang
    • Jinhyun Ryu
    • Joo Yeon Jeong
    • Dong Hoon Lee
    • Sang Soo Kang
  • View Affiliations

  • Published online on: November 30, 2018     https://doi.org/10.3892/or.2018.6898
  • Pages: 1377-1386
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Abstract

Zinc finger protein 36 (ZFP36) is an AU‑rich element protein that binds to 3'‑untranslated regions and promotes the decay of target mRNAs. Downregulation of ZFP36 expression in turn results in stabilization of target mRNAs. A recent study indicated that downregulation of ZFP36 expression in human liver cancer is caused by epigenetic mechanisms. The purpose of the present study was to investigate the potential of resveratrol (Res) to induce ZFP36 expression. Promoter methylation was analyzed using methylation‑sensitive restriction analysis. It was determined that Res treatment increased ZFP36 expression and decreased the mRNA levels of ZFP36 target genes in A549 lung cancer cells. Additionally, Res suppressed the expression of DNA (cytosine‑5)‑methyltransferase 1 and induced demethylation of the ZFP36 promoter. Collectively, the present results demonstrated that Res has anticancer activity through its epigenetic regulation of ZFP36 in non‑small cell lung cancer.
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February-2019
Volume 41 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Fudhaili A, Yoon NA, Kang S, Ryu J, Jeong JY, Lee DH and Kang SS: Resveratrol epigenetically regulates the expression of zinc finger protein 36 in non‑small cell lung cancer cell lines. Oncol Rep 41: 1377-1386, 2019.
APA
Fudhaili, A., Yoon, N.A., Kang, S., Ryu, J., Jeong, J.Y., Lee, D.H., & Kang, S.S. (2019). Resveratrol epigenetically regulates the expression of zinc finger protein 36 in non‑small cell lung cancer cell lines. Oncology Reports, 41, 1377-1386. https://doi.org/10.3892/or.2018.6898
MLA
Fudhaili, A., Yoon, N. A., Kang, S., Ryu, J., Jeong, J. Y., Lee, D. H., Kang, S. S."Resveratrol epigenetically regulates the expression of zinc finger protein 36 in non‑small cell lung cancer cell lines". Oncology Reports 41.2 (2019): 1377-1386.
Chicago
Fudhaili, A., Yoon, N. A., Kang, S., Ryu, J., Jeong, J. Y., Lee, D. H., Kang, S. S."Resveratrol epigenetically regulates the expression of zinc finger protein 36 in non‑small cell lung cancer cell lines". Oncology Reports 41, no. 2 (2019): 1377-1386. https://doi.org/10.3892/or.2018.6898