Linc01105 acts as an oncogene in the development of neuroblastoma

Corrigendum in: /10.3892/or.2021.8156

  • Authors:
    • Mujie Ye
    • Jing Ma
    • Baihui Liu
    • Xiangqi Liu
    • Duan Ma
    • Kuiran Dong
  • View Affiliations

  • Published online on: August 2, 2019     https://doi.org/10.3892/or.2019.7257
  • Pages: 1527-1538
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Abstract

Previous research from our group revealed that the long coding RNA (lncRNA) linc01105 is associated with neuroblastoma proliferation and apoptosis, and that its expression is correlated with the International Neuroblastoma Staging System stage. The purpose of the present study was to investigate the functions of Linc01105 in neuroblastoma. Lentivirus‑mediated linc01105 knockdown was performed in the neuroblastoma cell line SH‑SY5Y. The expression levels of linc01105 and of other associated genes were measured by reverse transcription‑quantitative PCR. Cell Counting Kit‑8 assay and flow cytometry were used to determine cell viability and apoptosis. The levels of proteins were detected using western blot analysis. Bioinformatics analysis and luciferase reporter assays were used to examine the relationship between linc01105, miR‑6769b‑5p and vascular endothelial growth factor A (VEGFA). Angiogenesis ability was measured using a tube formation assay. The results demonstrated that HIF‑1α overexpression promoted the transcription of linc01105 by acting as a transcription factor. Knockdown of linc01105 inhibited neuroblastoma cell proliferation, migration and invasion, and it induced apoptosis. In addition, linc01105 affected the expression of p53 and Bcl‑2 family proteins and activated the caspase signaling pathway. Further functional experiments revealed that linc01105 promoted the expression of the miR‑6769b‑5p target gene VEGFA by acting as a sponge of miR‑6769b‑5p. In conclusion, linc01105 may contribute to neuroblastoma tumorigenesis and development. The present findings indicated that the interplay between the p53/caspase pathway and the linc01105/miR‑6769b‑5p/VEGFA axis may have important roles in the development of neuroblastoma.
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October-2019
Volume 42 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ye M, Ma J, Liu B, Liu X, Ma D and Dong K: Linc01105 acts as an oncogene in the development of neuroblastoma Corrigendum in /10.3892/or.2021.8156. Oncol Rep 42: 1527-1538, 2019
APA
Ye, M., Ma, J., Liu, B., Liu, X., Ma, D., & Dong, K. (2019). Linc01105 acts as an oncogene in the development of neuroblastoma Corrigendum in /10.3892/or.2021.8156. Oncology Reports, 42, 1527-1538. https://doi.org/10.3892/or.2019.7257
MLA
Ye, M., Ma, J., Liu, B., Liu, X., Ma, D., Dong, K."Linc01105 acts as an oncogene in the development of neuroblastoma Corrigendum in /10.3892/or.2021.8156". Oncology Reports 42.4 (2019): 1527-1538.
Chicago
Ye, M., Ma, J., Liu, B., Liu, X., Ma, D., Dong, K."Linc01105 acts as an oncogene in the development of neuroblastoma Corrigendum in /10.3892/or.2021.8156". Oncology Reports 42, no. 4 (2019): 1527-1538. https://doi.org/10.3892/or.2019.7257