DDR1 promotes breast tumor growth by suppressing antitumor immunity

  • Authors:
    • Xing Zhong
    • Weiwei Zhang
    • Tianhao Sun
  • View Affiliations

  • Published online on: September 27, 2019     https://doi.org/10.3892/or.2019.7338
  • Pages: 2844-2854
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Abstract

Breast cancer is the second leading cause of cancer‑associated mortality among women worldwide. Triple‑negative breast cancer (TNBC) accounts for 15‑20% of all breast cancers and is defined by its aggressive nature and limited treatment options. Therefore, there is an urgent need to develop effective therapies for TNBC in order to improve breast cancer outcomes, as targeted therapies have done in other subtypes of breast cancer. Discoidin domain receptor tyrosine kinase 1 (DDR1) is activated by collagens, which are important components of the tumor stroma; therefore, DDR1 may serve a critical role in the communication between tumor cells and the tumor microenvironment. The aim of the present study was to determine how tumor DDR1 regulated tumor growth by affecting tumor infiltrated T cells. First, the DDR1 expression levels from a cohort of patients with breast cancer were analyzed. The results revealed that there were higher levels of DDR1 expression in tumor tissues compared with adjacent normal tissues. Overexpression of DDR1 in 4T1 cells promoted tumor growth in vivo, while knockout of DDR1 in EMT6 cells decreased tumor growth in vivo. In addition, it was revealed that DDR1 regulated tumor growth by modulating tumor infiltrating T cells, CD4+ and CD8+. Furthermore, inhibition of DDR1 by neutralizing antibodies decreased breast cancer growth in vivo. To the best of our knowledge, the results of the present study demonstrated for the first time that DDR1 expressed on the tumor cells promoted breast tumor growth by suppressing antitumor immunity. The present findings indicated that DDR1 may not only have a critical role in the progression of breast cancer, but may also serve as a potential therapeutic target for breast cancer, particularly TNBC.
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December-2019
Volume 42 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhong X, Zhang W and Sun T: DDR1 promotes breast tumor growth by suppressing antitumor immunity. Oncol Rep 42: 2844-2854, 2019.
APA
Zhong, X., Zhang, W., & Sun, T. (2019). DDR1 promotes breast tumor growth by suppressing antitumor immunity. Oncology Reports, 42, 2844-2854. https://doi.org/10.3892/or.2019.7338
MLA
Zhong, X., Zhang, W., Sun, T."DDR1 promotes breast tumor growth by suppressing antitumor immunity". Oncology Reports 42.6 (2019): 2844-2854.
Chicago
Zhong, X., Zhang, W., Sun, T."DDR1 promotes breast tumor growth by suppressing antitumor immunity". Oncology Reports 42, no. 6 (2019): 2844-2854. https://doi.org/10.3892/or.2019.7338