PD‑L1/PD‑1 blockade in breast cancer: The immunotherapy era (Review)

  • Authors:
    • Chia‑Jung Li
    • Li‑Te Lin
    • Ming‑Feng Hou
    • Pei‑Yi Chu
  • View Affiliations

  • Published online on: November 3, 2020     https://doi.org/10.3892/or.2020.7831
  • Pages: 5-12
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Abstract

Breast cancer is a common malignant tumor in women. Triple‑negative breast cancer (TNBC) is highly invasive with a high rate of metastasis and poor prognosis. Programmed death ligand 1 (PD‑L1) plays an important role in mediating the escape of tumor cells from immune surveillance. There have been significant advances in understanding the biology of TNBC. This review presents a detailed discourse on the available data on the expression of PD‑L1 in breast cancer and preliminary clinical outcome of PD‑L1/PD‑1 inhibitors in breast cancer patients. Early clinical trials involving PD‑L1/PD‑1 inhibitors have exhibited efficacy in tumor response and/or disease control in patients with refractory metastatic breast cancer, particularly TNBC. Furthermore, the mechanisms and factors that influence the immunoediting process are summarized and their functions in detail are analyzed.
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January-2021
Volume 45 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Li CJ, Lin LT, Hou MF and Chu PY: PD‑L1/PD‑1 blockade in breast cancer: The immunotherapy era (Review). Oncol Rep 45: 5-12, 2021.
APA
Li, C., Lin, L., Hou, M., & Chu, P. (2021). PD‑L1/PD‑1 blockade in breast cancer: The immunotherapy era (Review). Oncology Reports, 45, 5-12. https://doi.org/10.3892/or.2020.7831
MLA
Li, C., Lin, L., Hou, M., Chu, P."PD‑L1/PD‑1 blockade in breast cancer: The immunotherapy era (Review)". Oncology Reports 45.1 (2021): 5-12.
Chicago
Li, C., Lin, L., Hou, M., Chu, P."PD‑L1/PD‑1 blockade in breast cancer: The immunotherapy era (Review)". Oncology Reports 45, no. 1 (2021): 5-12. https://doi.org/10.3892/or.2020.7831