CD155/TIGIT, a novel immune checkpoint in human cancers (Review)

  • Authors:
    • Lu Liu
    • Xuewu You
    • Sai Han
    • Yu Sun
    • Junhua Zhang
    • Youzhong Zhang
  • View Affiliations

  • Published online on: January 19, 2021     https://doi.org/10.3892/or.2021.7943
  • Pages: 835-845
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Abstract

CD155/T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a novel type of immune checkpoint. CD155 is an adhesion molecule that is upregulated during tumor progression and promotes the proliferative and migratory abilities of tumor cells via various pathways. TIGIT, an inhibitory receptor, is mainly expressed on natural killer (NK), CD8+ T, CD4+ T and T regulatory (Treg) cells. CD155 transmits immune signals via interacting with the inhibitory checkpoint receptor TIGIT, thereby inhibiting the function of T and NK cells. Several preclinical studies have supported the use of TIGIT blockade as a monotherapy or combined with other immune checkpoint inhibitors for the treatment of advanced solid malignant tumors. The present review summarized the current knowledge on CD155/TIGIT and the lymphocyte‑mediated inhibitory mechanism of CD155/TIGIT. An in‑depth understanding of the role of CD155/TIGIT in tumors may aid to improve the application of immune checkpoint inhibitors in tumor therapy.
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March-2021
Volume 45 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Liu L, You X, Han S, Sun Y, Zhang J and Zhang Y: CD155/TIGIT, a novel immune checkpoint in human cancers (Review). Oncol Rep 45: 835-845, 2021.
APA
Liu, L., You, X., Han, S., Sun, Y., Zhang, J., & Zhang, Y. (2021). CD155/TIGIT, a novel immune checkpoint in human cancers (Review). Oncology Reports, 45, 835-845. https://doi.org/10.3892/or.2021.7943
MLA
Liu, L., You, X., Han, S., Sun, Y., Zhang, J., Zhang, Y."CD155/TIGIT, a novel immune checkpoint in human cancers (Review)". Oncology Reports 45.3 (2021): 835-845.
Chicago
Liu, L., You, X., Han, S., Sun, Y., Zhang, J., Zhang, Y."CD155/TIGIT, a novel immune checkpoint in human cancers (Review)". Oncology Reports 45, no. 3 (2021): 835-845. https://doi.org/10.3892/or.2021.7943