Direct and indirect anticancer effects of hyperthermic intraperitoneal chemotherapy on peritoneal malignancies (Review)

  • Authors:
    • Ying Zhang
    • Yumin Wu
    • Jun Wu
    • Chen Wu
  • View Affiliations

  • Published online on: February 10, 2021     https://doi.org/10.3892/or.2021.7974
  • Article Number: 23
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Abstract

The successful application of hyperthermic intraperitoneal chemotherapy (HIPEC) illustrates its antitumor activity against primary malignances and peritoneal metastases. Although the specific underlying molecular mechanisms remain unclear, increasing evidence suggest that HIPEC directly and indirectly inhibits tumor growth, and prolongs overall survival in both hyperthermic and chemotherapeutic manners. To demonstrate the superiority and limitations of such a therapeutic regimen, the present review focuses on the biological and immunological anticancer mechanisms of HIPEC. In addition, the potential combination of HIPEC with other therapies is discussed, as well as its potential to prolong the overall survival time of patients with peritoneal malignancies.
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April-2021
Volume 45 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhang Y, Wu Y, Wu J and Wu C: Direct and indirect anticancer effects of hyperthermic intraperitoneal chemotherapy on peritoneal malignancies (Review). Oncol Rep 45: 23, 2021.
APA
Zhang, Y., Wu, Y., Wu, J., & Wu, C. (2021). Direct and indirect anticancer effects of hyperthermic intraperitoneal chemotherapy on peritoneal malignancies (Review). Oncology Reports, 45, 23. https://doi.org/10.3892/or.2021.7974
MLA
Zhang, Y., Wu, Y., Wu, J., Wu, C."Direct and indirect anticancer effects of hyperthermic intraperitoneal chemotherapy on peritoneal malignancies (Review)". Oncology Reports 45.4 (2021): 23.
Chicago
Zhang, Y., Wu, Y., Wu, J., Wu, C."Direct and indirect anticancer effects of hyperthermic intraperitoneal chemotherapy on peritoneal malignancies (Review)". Oncology Reports 45, no. 4 (2021): 23. https://doi.org/10.3892/or.2021.7974