Open Access

Long non‑coding RNAs interact with RNA‑binding proteins to regulate genomic instability in cancer cells (Review)

  • Authors:
    • Kai Yang
    • Xiaoxiang Liang
    • Kunming Wen
  • View Affiliations

  • Published online on: August 19, 2022     https://doi.org/10.3892/or.2022.8390
  • Article Number: 175
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Genomic instability, a feature of most cancers, contributes to malignant cell transformation and cancer progression due to the accumulation of genetic alterations. Genomic instability is reflected at numerous levels, from single nucleotide to the chromosome levels. However, the exact molecular mechanisms and regulators of genomic instability in cancer remain unclear. Growing evidence indicates that the binding of long non‑coding RNAs (lncRNAs) to protein chaperones confers a variety of regulatory functions, including managing of genomic instability. The aim of the present review was to examine the roles of mitosis, telomeres, DNA repair, and epigenetics in genomic instability, and the mechanisms by which lncRNAs regulate them by binding proteins in cancer cells. This review contributes to our understanding of the role of lncRNAs and genomic instability in cancer and can potentially provide entry points and molecular targets for cancer therapies.
View Figures
View References

Related Articles

Journal Cover

October-2022
Volume 48 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yang K, Liang X and Wen K: Long non‑coding RNAs interact with RNA‑binding proteins to regulate genomic instability in cancer cells (Review). Oncol Rep 48: 175, 2022.
APA
Yang, K., Liang, X., & Wen, K. (2022). Long non‑coding RNAs interact with RNA‑binding proteins to regulate genomic instability in cancer cells (Review). Oncology Reports, 48, 175. https://doi.org/10.3892/or.2022.8390
MLA
Yang, K., Liang, X., Wen, K."Long non‑coding RNAs interact with RNA‑binding proteins to regulate genomic instability in cancer cells (Review)". Oncology Reports 48.4 (2022): 175.
Chicago
Yang, K., Liang, X., Wen, K."Long non‑coding RNAs interact with RNA‑binding proteins to regulate genomic instability in cancer cells (Review)". Oncology Reports 48, no. 4 (2022): 175. https://doi.org/10.3892/or.2022.8390