Xiaotan Sanjie decoction normalizes tumor permissive microenvironment in gastric cancer (Review)

  • Authors:
    • Da-Zhi Sun
    • Pin-Kang Wei
    • Xiao-Qiang Yue
  • View Affiliations

  • Published online on: February 28, 2023     https://doi.org/10.3892/or.2023.8511
  • Article Number: 74
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Abstract

Gastric cancer (GC) develops in a complex tissue environment, the tumor microenvironment (TME), which it relies on for persistent proliferation, migration, invasion and metastasis. Non‑malignant stromal cell types within the TME are regarded as a clinical meaningful target with the lower risk of resistance and tumor relapse. Studies have revealed that the Xiaotan Sanjie decoction, which is formulated on the basis of the theory of phlegm syndrome, a Traditional Chinese Medicine concept, modulates released factors such as transforming growth factor‑β from tumor cells, immune cells, cancer‑associated fibroblasts, extracellular matrix, as well as vascular endothelial growth factor involved in the process of angiogenesis within the TME. Clinical studies have also shown that the Xiaotan Sanjie decoction is associated with favorable survival and quality of life. The present review aimed to interpret the hypothesis that Xiaotan Sanjie decoction has the ability to normalize the GC tumor cells by influencing functions of stromal cells within the TME. The possible association between phlegm syndrome and the TME in GC was discussed in the present review. Overall, Xiaotan Sanjie decoction may be suitable to be added to tumor cell‑directed agents or emerging immunotherapies becoming a desirable modality in the management of GC and acquire improved outcomes for patients with GC.
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April-2023
Volume 49 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Sun D, Wei P and Yue X: Xiaotan Sanjie decoction normalizes tumor permissive microenvironment in gastric cancer (Review). Oncol Rep 49: 74, 2023
APA
Sun, D., Wei, P., & Yue, X. (2023). Xiaotan Sanjie decoction normalizes tumor permissive microenvironment in gastric cancer (Review). Oncology Reports, 49, 74. https://doi.org/10.3892/or.2023.8511
MLA
Sun, D., Wei, P., Yue, X."Xiaotan Sanjie decoction normalizes tumor permissive microenvironment in gastric cancer (Review)". Oncology Reports 49.4 (2023): 74.
Chicago
Sun, D., Wei, P., Yue, X."Xiaotan Sanjie decoction normalizes tumor permissive microenvironment in gastric cancer (Review)". Oncology Reports 49, no. 4 (2023): 74. https://doi.org/10.3892/or.2023.8511