Open Access

Oncogenic role of FOXM1 in human prostate cancer (Review)

  • Authors:
    • Da Young Lee
    • Jung Nyeo Chun
    • Insuk So
    • Ju-Hong Jeon
  • View Affiliations

  • Published online on: November 30, 2023     https://doi.org/10.3892/or.2023.8674
  • Article Number: 15
  • Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Prostate cancer is the leading cause of cancer‑related mortality among men worldwide. In particular, castration‑resistant prostate cancer presents a formidable clinical challenge and emphasizes the need to develop novel therapeutic strategies. Forkhead box M1 (FOXM1) is a multifaceted transcription factor that is implicated in the acquisition of the multiple cancer hallmark capabilities in prostate cancer cells, including sustaining proliferative signaling, resisting cell death and the activation of invasion and metastasis. Elevated FOXM1 expression is frequently observed in prostate cancer, and in particular, FOXM1 overexpression is closely associated with poor clinical outcomes in patients with prostate cancer. In the present review, recent advances in the understanding of the oncogenic role of deregulated FOXM1 expression in prostate cancer were highlighted. In addition, the molecular mechanisms by which FOXM1 regulates prostate cancer development and progression were described, thereby providing knowledge and a conceptual framework for FOXM1. The present review also provided valuable insight into the inherent challenges associated with translating biomedical knowledge into effective therapeutic strategies for prostate cancer.
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January-2024
Volume 51 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Lee DY, Chun JN, So I and Jeon J: Oncogenic role of FOXM1 in human prostate cancer (Review). Oncol Rep 51: 15, 2024.
APA
Lee, D.Y., Chun, J.N., So, I., & Jeon, J. (2024). Oncogenic role of FOXM1 in human prostate cancer (Review). Oncology Reports, 51, 15. https://doi.org/10.3892/or.2023.8674
MLA
Lee, D. Y., Chun, J. N., So, I., Jeon, J."Oncogenic role of FOXM1 in human prostate cancer (Review)". Oncology Reports 51.1 (2024): 15.
Chicago
Lee, D. Y., Chun, J. N., So, I., Jeon, J."Oncogenic role of FOXM1 in human prostate cancer (Review)". Oncology Reports 51, no. 1 (2024): 15. https://doi.org/10.3892/or.2023.8674