Mitochondrial‑associated endoplasmic reticulum membrane interference in ovarian cancer (Review)

Dong,Yi-Fan; Zhang,Jiaheng; Zhou,Jin-Hong; Xiao,Yi-Li; Pei,Wan-Juan; Liu,Hui-Ping

doi:10.3892/or.2024.8771

Mitochondrial‑associated endoplasmic reticulum membrane interference in ovarian cancer (Review)

Authors:
- Yi-Fan Dong
- Jiaheng Zhang
- Jin-Hong Zhou
- Yi-Li Xiao
- Wan-Juan Pei
- Hui-Ping Liu
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Affiliations: College of Integrative Medicine, Hunan University of Traditional Chinese Medicine, Changsha, Hunan 410208, P.R. China
Published online on: July 3, 2024 https://doi.org/10.3892/or.2024.8771
Article Number: 112

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Abstract

The mitochondria‑associated endoplasmic reticulum (ER) membrane (MAM), serving as a vital link between the mitochondria and ER, holds a pivotal role in maintaining the physiological function of these two organelles. Its specific functions encompass the participation in the biosynthesis and functional regulation of the mitochondria, calcium ion transport, lipid metabolism, oxidative stress and autophagy among numerous other facets. Scientific exploration has revealed that MAMs hold potential as effective therapeutic targets influencing the mitochondria and ER within the context of cancer therapy. The present review focused on elucidating the related pathways of mitochondrial autophagy and ER stress and their practical application in ovarian cancer, aiming to identify commonalities existing between MAMs and these pathways, thereby extending to related applications of MAMs in ovarian cancer treatment. This endeavor aimed at exploring new potential for MAMs in clinically managing ovarian cancer.

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