Open Access

Emerging role of sirtuins in non‑small cell lung cancer (Review)

  • Authors:
    • Min Zhou
    • Lin Wei
    • Renfu Lu
  • View Affiliations

  • Published online on: July 30, 2024     https://doi.org/10.3892/or.2024.8786
  • Article Number: 127
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Non‑small cell lung cancer (NSCLC) is a highly prevalent lung malignancy characterized by insidious onset, rapid progression and advanced stage at the time of diagnosis, making radical surgery impossible. Sirtuin (SIRT) is a histone deacetylase that relies on NAD+ for its function, regulating the aging process through modifications in protein activity and stability. It is intricately linked to various processes, including glycolipid metabolism, inflammation, lifespan regulation, tumor formation and stress response. An increasing number of studies indicate that SIRTs significantly contribute to the progression of NSCLC by regulating pathophysiological processes such as energy metabolism, autophagy and apoptosis in tumor cells through the deacetylation of histones or non‑histone proteins. The present review elaborates on the roles of different SIRTs and their mechanisms in NSCLC, while also summarizing novel therapeutic agents based on SIRTs. It aims to present new ideas and a theoretical basis for NSCLC treatment.
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October-2024
Volume 52 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhou M, Wei L and Lu R: Emerging role of sirtuins in non‑small cell lung cancer (Review). Oncol Rep 52: 127, 2024
APA
Zhou, M., Wei, L., & Lu, R. (2024). Emerging role of sirtuins in non‑small cell lung cancer (Review). Oncology Reports, 52, 127. https://doi.org/10.3892/or.2024.8786
MLA
Zhou, M., Wei, L., Lu, R."Emerging role of sirtuins in non‑small cell lung cancer (Review)". Oncology Reports 52.4 (2024): 127.
Chicago
Zhou, M., Wei, L., Lu, R."Emerging role of sirtuins in non‑small cell lung cancer (Review)". Oncology Reports 52, no. 4 (2024): 127. https://doi.org/10.3892/or.2024.8786