Open Access

Lactate and lactylation in gastrointestinal cancer: Current progress and perspectives (Review)

  • Authors:
    • Yufen He
    • Yaxi Huang
    • Peng Peng
    • Qi Yan
    • Lidan Ran
  • View Affiliations

  • Published online on: November 8, 2024     https://doi.org/10.3892/or.2024.8839
  • Article Number: 6
  • Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastrointestinal (GI) cancers, which have notable incidence and mortality, are impacted by metabolic reprogramming, especially the increased production and accumulation of lactate. Lactylation, a post‑translational modification driven by lactate, is a crucial regulator of gene expression and cellular function in GI cancer. The present review aimed to examine advancements in understanding lactate and lactylation in GI cancer. The mechanisms of lactate production, its influence on the tumor microenvironment and the clinical implications of lactate levels as potential biomarkers were explored. Furthermore, lactylation was investigated, including its biochemical foundation, primary targets and functional outcomes. The present review underscored potential therapeutic strategies targeting lactate metabolism and lactylation. Challenges and future directions emphasize the potential of lactate and lactylation as innovative therapeutic targets in GI cancer to improve clinical outcomes.
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January-2025
Volume 53 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
He Y, Huang Y, Peng P, Yan Q and Ran L: Lactate and lactylation in gastrointestinal cancer: Current progress and perspectives (Review). Oncol Rep 53: 6, 2025.
APA
He, Y., Huang, Y., Peng, P., Yan, Q., & Ran, L. (2025). Lactate and lactylation in gastrointestinal cancer: Current progress and perspectives (Review). Oncology Reports, 53, 6. https://doi.org/10.3892/or.2024.8839
MLA
He, Y., Huang, Y., Peng, P., Yan, Q., Ran, L."Lactate and lactylation in gastrointestinal cancer: Current progress and perspectives (Review)". Oncology Reports 53.1 (2025): 6.
Chicago
He, Y., Huang, Y., Peng, P., Yan, Q., Ran, L."Lactate and lactylation in gastrointestinal cancer: Current progress and perspectives (Review)". Oncology Reports 53, no. 1 (2025): 6. https://doi.org/10.3892/or.2024.8839