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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 1996 Volume 3 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1996 Volume 3 Issue 3

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Article

DNA-protein crosslinks as a biomarker of cis-platinum activity in cancer patients

  • Authors:
    • E Taioli
    • A Zhitkovich
    • P Toniolo
    • J Bernstein
    • R Blum
    • M Costa

  • View Affiliations / Copyright

    Affiliations: NYU,MED CTR,DEPT MED,NEW YORK,NY 10010. NYU,MED CTR,KAPLAN COMPREHENS CANC CTR,NEW YORK,NY 10010. MT SINAI MED CTR,DEPT COMMUNITY MED,NEW YORK,NY 10029.
  • Pages: 439-441
    |
    Published online on: May 1, 1996
       https://doi.org/10.3892/or.3.3.439
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Abstract

We have developed a new method to assess the amount of DNA-protein crosslinks (DNA-PC) in peripheral lymphocytes, based on the selective precipitation of the DNA crosslinked to proteins. We assessed the amount of DNA-PC in peripheral lymphocytes of 18 cancer patients who underwent chemotherapy with cis-platinum for the first time. Since the chemotherapy was administered over a two-day period, blood samples were drawn at baseline (before starting the therapy), 4 h after the infusion of the first dose of cis-platinum, the next day (24 h after the first dose, and immediately before the infusion of the second dose), and 2 days later (48 h after the first dose). The mean change of DNA-PC 4 h after therapy was 0.8+/-0.8% (p=0.006), 0.5+/-0.6% after 1 day (p=0.007), and 0.1+/-0.5% after two days (ns). The correlation between DNA-PC changes and cumulative dose of cis-platinum was -0.22 at 4 h, -0.19 after 1 day, and -0.68 at 2 days (p=0.005). The crosslinking effect of cis-platinum seems to vary among individuals and with dose; the DNA-PC may be used to define sub-populations of patients with various degree of sensitivity to the pharmacologic action of this chemotherapeutic agent, and thus to adjust the dosage on an individual basis.

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Copy and paste a formatted citation
Spandidos Publications style
Taioli E, Zhitkovich A, Toniolo P, Bernstein J, Blum R and Costa M: DNA-protein crosslinks as a biomarker of cis-platinum activity in cancer patients. Oncol Rep 3: 439-441, 1996.
APA
Taioli, E., Zhitkovich, A., Toniolo, P., Bernstein, J., Blum, R., & Costa, M. (1996). DNA-protein crosslinks as a biomarker of cis-platinum activity in cancer patients. Oncology Reports, 3, 439-441. https://doi.org/10.3892/or.3.3.439
MLA
Taioli, E., Zhitkovich, A., Toniolo, P., Bernstein, J., Blum, R., Costa, M."DNA-protein crosslinks as a biomarker of cis-platinum activity in cancer patients". Oncology Reports 3.3 (1996): 439-441.
Chicago
Taioli, E., Zhitkovich, A., Toniolo, P., Bernstein, J., Blum, R., Costa, M."DNA-protein crosslinks as a biomarker of cis-platinum activity in cancer patients". Oncology Reports 3, no. 3 (1996): 439-441. https://doi.org/10.3892/or.3.3.439
Copy and paste a formatted citation
x
Spandidos Publications style
Taioli E, Zhitkovich A, Toniolo P, Bernstein J, Blum R and Costa M: DNA-protein crosslinks as a biomarker of cis-platinum activity in cancer patients. Oncol Rep 3: 439-441, 1996.
APA
Taioli, E., Zhitkovich, A., Toniolo, P., Bernstein, J., Blum, R., & Costa, M. (1996). DNA-protein crosslinks as a biomarker of cis-platinum activity in cancer patients. Oncology Reports, 3, 439-441. https://doi.org/10.3892/or.3.3.439
MLA
Taioli, E., Zhitkovich, A., Toniolo, P., Bernstein, J., Blum, R., Costa, M."DNA-protein crosslinks as a biomarker of cis-platinum activity in cancer patients". Oncology Reports 3.3 (1996): 439-441.
Chicago
Taioli, E., Zhitkovich, A., Toniolo, P., Bernstein, J., Blum, R., Costa, M."DNA-protein crosslinks as a biomarker of cis-platinum activity in cancer patients". Oncology Reports 3, no. 3 (1996): 439-441. https://doi.org/10.3892/or.3.3.439
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