Probucol decreases total body fat loss in VX2-carcinoma-induced cachectic rabbits
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- Published online on: November 1, 2001 https://doi.org/10.3892/or.8.6.1309
- Pages: 1309-1311
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Abstract
We previously reported the continuous decrease of total body fat in VX2-carcinoma-bearing rabbits after tumor implantation, as well as changes in the serum lipid profile. Probucol, an antioxidant drug, has a cholesterol lowering effect against hyperlipidemic subjects. VX2-carcinoma-bearing rabbits fed with a diet containing 1% probucol did not show any difference in serum lipid compositions as compared with rabbits fed with a control diet. Similarly serum lipolytic activity showed no differences, whether probucol was administered or not, while the decrease in total body fat was significantly less when probucol was administered.
