Survival after cytotoxic chemotherapy in patients with advanced hormone-resistant prostate cancer: A phase II study

  • Authors:
    • George P. Stathopoulos
    • John Koutantos
    • Michael M. Vaslamatzis
    • Athanasios Athanasiadis
    • George Papadopoulos
    • G. Labrodimou
    • John Stathopoulos
    • Sotiris Rigatos
  • View Affiliations

  • Published online on: August 1, 2009     https://doi.org/10.3892/or_00000443
  • Pages: 345-348
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Abstract

In the past, it was believed that when advanced-stage prostate cancer became resistant to hormonal management, no chemotherapy should be administered, as survival was not prolonged. Mitoxanthrone and prednisone were mostly administered, while recently, other agents such as docetaxel or paclitaxel have been tested both with and without hormonal treatment. The objective of the present phase II study was to determine the survival and the response rate of patients after the chemotherapy was administered. Sixty-five patients with advanced prostate cancer were included. The inclusion criteria involved histological confirmation of adenocarcinoma and resistance to hormonal therapy. The majority of the patients had stage IVa or IVb disease and a performance status of 0-1 to 2. The treatment involved chemotherapy in combination with a luteinizing hormone-releasing hormone (LHRH) or dexamethasone or estramustine. The hormone treatment preceded the cytotoxic administration and no amelioration in the patients nor prostate serum antigen (PSA) reduction was observed. The initial cytotoxic agents administered were docetaxel 75 mg/m2 in 25 patients, mitoxanthrone 10 mg/m2 in 15 patients, epirubicin 75 mg/m2 in 15 patients and paclitaxel 175 mg/m2 in 10 patients, all repeated every 3 weeks. The response rate was documented by bone scan, CT scan of the abdomen (and occasionally of the chest) and by the PSA serum value. Clinical benefit was also estimated. Thirty-three (50.77%) patients achieved a partial response; stable disease was observed in 24 (36.92%) patients and disease progression in 8 (12.31%). Twenty-two (33.85%) experienced clinical benefit. A significant PSA reduction was seen in 35 (53.85%) patients. The median survival was 18 months and the range 3-84 months. One, 2, 3 and five-year survival was 75.38, 23.07, 12.30 and 4.66%, respectively. Toxicity was well-tolerated. Patients with hormone-resistant advanced prostate cancer do have good prospects for receiving substantial benefit with the addition of chemotherapy, as observed in the present trial.

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August 2009
Volume 22 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Stathopoulos GP, Koutantos J, Vaslamatzis MM, Athanasiadis A, Papadopoulos G, Labrodimou G, Stathopoulos J and Rigatos S: Survival after cytotoxic chemotherapy in patients with advanced hormone-resistant prostate cancer: A phase II study. Oncol Rep 22: 345-348, 2009.
APA
Stathopoulos, G.P., Koutantos, J., Vaslamatzis, M.M., Athanasiadis, A., Papadopoulos, G., Labrodimou, G. ... Rigatos, S. (2009). Survival after cytotoxic chemotherapy in patients with advanced hormone-resistant prostate cancer: A phase II study. Oncology Reports, 22, 345-348. https://doi.org/10.3892/or_00000443
MLA
Stathopoulos, G. P., Koutantos, J., Vaslamatzis, M. M., Athanasiadis, A., Papadopoulos, G., Labrodimou, G., Stathopoulos, J., Rigatos, S."Survival after cytotoxic chemotherapy in patients with advanced hormone-resistant prostate cancer: A phase II study". Oncology Reports 22.2 (2009): 345-348.
Chicago
Stathopoulos, G. P., Koutantos, J., Vaslamatzis, M. M., Athanasiadis, A., Papadopoulos, G., Labrodimou, G., Stathopoulos, J., Rigatos, S."Survival after cytotoxic chemotherapy in patients with advanced hormone-resistant prostate cancer: A phase II study". Oncology Reports 22, no. 2 (2009): 345-348. https://doi.org/10.3892/or_00000443