Constitutive NF-κB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma

  • Authors:
    • Tong-Xin Xie
    • Zhibo Xia
    • Nu Zhang
    • Weida Gong
    • Suyun Huang
  • View Affiliations

  • Published online on: March 1, 2010     https://doi.org/10.3892/or_00000690
  • Pages: 725-732
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Abstract

Angiogenesis is a key pathologic feature of glioblastoma, which is the most common and most lethal primary brain tumor in adults. The degree of angiogenesis has been shown to be inversely related to patient survival. However, the molecular changes leading to angiogenesis in glioblastoma remain poorly understood. In the present study, we found a direct correlation between nuclear factor (NF)-κB activation and angiogenesis in glioblastomas. Blockade of NF-κB signaling significantly inhibited glioblastoma growth and angiogenesis in nude mice. These effects were consistent with significant inhibition of the expression of multiple angiogenic molecules, including vascular endothelial growth factor, and interleukin-8, in vitro and in vivo. Furthermore, blockade of NF-κB signaling also significantly inhibited the angiogenic potential of glioblastoma cells in vitro and angiogenesis of brain tumors in mouse xenograft models. Collectively, these results suggest that NF-κB activation plays a critical role in the growth and progression of glioblastoma and is a potential target for therapy for human glioblastoma.

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March 2010
Volume 23 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Xie T, Xia Z, Zhang N, Gong W and Huang S: Constitutive NF-κB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma. Oncol Rep 23: 725-732, 2010.
APA
Xie, T., Xia, Z., Zhang, N., Gong, W., & Huang, S. (2010). Constitutive NF-κB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma. Oncology Reports, 23, 725-732. https://doi.org/10.3892/or_00000690
MLA
Xie, T., Xia, Z., Zhang, N., Gong, W., Huang, S."Constitutive NF-κB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma". Oncology Reports 23.3 (2010): 725-732.
Chicago
Xie, T., Xia, Z., Zhang, N., Gong, W., Huang, S."Constitutive NF-κB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma". Oncology Reports 23, no. 3 (2010): 725-732. https://doi.org/10.3892/or_00000690