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A pivotal role for Pim-1 kinase in esophageal squamous cell carcinoma involving cell apoptosis induced by reducing Akt phosphorylation

  • Authors:
    • Shenglei Li
    • Yu Xi
    • Hongyan Zhang
    • Yange Wang
    • Xin Wang
    • Hongtao Liu
    • Kuisheng Chen

  • View Affiliations

  • Published online on: October 1, 2010     https://doi.org/10.3892/or_00000947
  • Pages: 997-1004
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

It is well documented that Provirus integration site for Moloney murine leukemia virus 1 (Pim-1), as a proto-oncogene encoding a serine/threonine kinase with multiple cellular functions, is tightly associated with the occurrence and development of tumors. Overexpression of Pim-1 plays a critical role in the progression of several different tumors. In this study, esophageal squamous cell carcinoma (ESCC) EC9706 cells with Pim-1 siRNA treatment resulted in a clear decrease of Pim-1 levels, followed by inhibiting cell proliferation and inducing apoptosis. Further, Pim-1 siRNA reduced phosphorylation of Akt and Bad, and increased cleaved caspase-3/-9 activities and expression levels. These data suggest that Pim-1 siRNA-mediated apoptosis is closely related to the decrease in Akt and Bad phosphorylation and increase in cleaved caspase-3/-9 activities, and thus manipulation of Pim-1 is a potential target for molecular therapy in the clinical treatment of patients with ESCC.

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Journal Cover

October 2010
Volume 24 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 3.8
  • Ranked Oncology
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Li S, Xi Y, Zhang H, Wang Y, Wang X, Liu H and Chen K: A pivotal role for Pim-1 kinase in esophageal squamous cell carcinoma involving cell apoptosis induced by reducing Akt phosphorylation . Oncol Rep 24: 997-1004, 2010.
APA
Li, S., Xi, Y., Zhang, H., Wang, Y., Wang, X., Liu, H., & Chen, K. (2010). A pivotal role for Pim-1 kinase in esophageal squamous cell carcinoma involving cell apoptosis induced by reducing Akt phosphorylation . Oncology Reports, 24, 997-1004. https://doi.org/10.3892/or_00000947
MLA
Li, S., Xi, Y., Zhang, H., Wang, Y., Wang, X., Liu, H., Chen, K."A pivotal role for Pim-1 kinase in esophageal squamous cell carcinoma involving cell apoptosis induced by reducing Akt phosphorylation ". Oncology Reports 24.4 (2010): 997-1004.
Chicago
Li, S., Xi, Y., Zhang, H., Wang, Y., Wang, X., Liu, H., Chen, K."A pivotal role for Pim-1 kinase in esophageal squamous cell carcinoma involving cell apoptosis induced by reducing Akt phosphorylation ". Oncology Reports 24, no. 4 (2010): 997-1004. https://doi.org/10.3892/or_00000947