Survivin as a novel target protein for reducing the proliferation of cancer cells (Review)

  • Authors:
    • Dongyu Li
    • Chenghao Hu
    • Huibin Li
  • View Affiliations

  • Published online on: March 13, 2018     https://doi.org/10.3892/br.2018.1077
  • Pages:399-406
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Abstract

Survivin, also known as baculoviral inhibitor of apoptosis repeat‑containing 5, is a novel member of the inhibitor of apoptosis protein family. Survivin is highly expressed in tumors and embryonic tissues and is associated with tumor cell differentiation, proliferation, invasion and metastasis; however, survivin is expressed at low levels in normal terminally differentiated adult tissues. Meanwhile, the expression level of survivin is also a negative prognostic factor for patients with cancer. These unique characteristics of survivin make it an exciting potential therapeutic target for cancer treatment. This review will discuss the biological characteristics of survivin and its potential use as a treatment target to reduce cancer cell proliferation.

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May 2018
Volume 8 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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APA
Li, D., Hu, C., & Li, H. (2018). Survivin as a novel target protein for reducing the proliferation of cancer cells (Review). Biomedical Reports, 8, 399-406. https://doi.org/10.3892/br.2018.1077
MLA
Li, D., Hu, C., Li, H."Survivin as a novel target protein for reducing the proliferation of cancer cells (Review)". Biomedical Reports 8.5 (2018): 399-406.
Chicago
Li, D., Hu, C., Li, H."Survivin as a novel target protein for reducing the proliferation of cancer cells (Review)". Biomedical Reports 8, no. 5 (2018): 399-406. https://doi.org/10.3892/br.2018.1077