Open Access

Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke (Review)

  • Authors:
    • Yingchen Li
    • Qilai Cheng
    • Guoheng Hu
    • Tianhao Deng
    • Qimei Wang
    • Jianda Zhou
    • Xinping Su
  • View Affiliations

  • Published online on: March 22, 2018     https://doi.org/10.3892/etm.2018.5993
  • Pages:4067-4079
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

A stroke is a focal cerebral insult that frequently causes severe neurological deficit and mortality. Recent studies have demonstrated that multipotent mesenchymal stromal cells (MSCs) hold great promise for neurovascular remodeling and neurological function recovery following a stroke. Rather than a direct replacement of parenchymal brain cells, the therapeutic mechanism of MSCs is suggested to be the secretion of soluble factors. Specifically, emerging data described MSCs as being able to release extracellular vesicles (EVs), which contain a variety of cargo including proteins, lipids, DNA and various RNA species. The released EVs can target neurocytes and vascular cells and modify the cell's functions by delivering the cargo, which are considered to mediate the neural restoration effects of MSCs. Therefore, EVs may be developed as a novel cell‑free therapy for neurological disorders. In the present review, the current advances regarding the components, functions and therapeutic potential of EVs are summarized and the use of MSC‑derived EVs as a promising approach in the treatment of stroke are highlighted.

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Journal Cover

May 2018
Volume 15 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
(total number of cites)

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APA
Li, Y., Cheng, Q., Hu, G., Deng, T., Wang, Q., Zhou, J., & Su, X. (2018). Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke (Review). Experimental and Therapeutic Medicine, 15, 4067-4079. https://doi.org/10.3892/etm.2018.5993
MLA
Li, Y., Cheng, Q., Hu, G., Deng, T., Wang, Q., Zhou, J., Su, X."Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke (Review)". Experimental and Therapeutic Medicine 15.5 (2018): 4067-4079.
Chicago
Li, Y., Cheng, Q., Hu, G., Deng, T., Wang, Q., Zhou, J., Su, X."Extracellular vesicles in mesenchymal stromal cells: A novel therapeutic strategy for stroke (Review)". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4067-4079. https://doi.org/10.3892/etm.2018.5993