Chronic inflammation and cancer: Targeting chronic inflammatory mediators for the prevention and treatment of cancers

Chronic inflammation has emerged as a central player in the development and progression of cancer. This complex relationship involves a cascade of immunological and molecular events that collectively contribute to tumorigenesis. Persistent inflammation leads to the release of pro-inflammatory cytokines, oxidative stress, and DNA damage, creating an environment conducive to the growth and survival of malignant cells. Immune evasion and tissue remodeling further facilitate cancer progression. Notably, several cancers, including colorectal, liver, lung, and gastric cancer, have well-established links to chronic inflammation. Understanding the interplay between chronic inflammation and cancer is crucial for advancing cancer prevention and treatment strategies. This special issue aims to publish studies that discern the molecular mechanisms of chronic inflammation leading to cancer, as well as strategies, including the development of new drug candidates targeting inflammatory mediators for cancer prevention and treatment.

19/03/2025