Open Access

Regulatory B cells in infectious disease (Review)

  • Authors:
    • You‑Chao Dai
    • Jixin Zhong
    • Jun‑Fa Xu
  • View Affiliations

  • Published online on: May 18, 2017     https://doi.org/10.3892/mmr.2017.6605
  • Pages:3-10
  • Copyright: © Dai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Regulatory B cells (Bregs) are a subset of B cells, which reportedly exert significant immunomodulatory effects through the production of interleukin (IL)‑10, IL‑35 and transforming growth factor‑β. Over the last decade, studies have indicated that Bregs function in autoimmune and allergic diseases through antigen‑specific and non‑specific immunoregulatory mechanisms. However, only a limited number of reviews have focused on the role of Bregs during infection, particularly their functions in intracellular infections. The present review discusses the role of Bregs in infectious diseases in animal models and human studies, and provides an overview of the immunoregulatory mechanisms used by Bregs.

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Journal Cover

July 2017
Volume 16 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

2016 Impact Factor: 1.692
Ranked #19/128 Medicine Research and Experimental
(total number of cites)

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Copy and paste a formatted citation
APA
Dai, Y., Zhong, J., & Xu, J. (2017). Regulatory B cells in infectious disease (Review). Molecular Medicine Reports, 16, 3-10. https://doi.org/10.3892/mmr.2017.6605
MLA
Dai, Y., Zhong, J., Xu, J."Regulatory B cells in infectious disease (Review)". Molecular Medicine Reports 16.1 (2017): 3-10.
Chicago
Dai, Y., Zhong, J., Xu, J."Regulatory B cells in infectious disease (Review)". Molecular Medicine Reports 16, no. 1 (2017): 3-10. https://doi.org/10.3892/mmr.2017.6605