Role of Wnt signaling pathway in lung cancer

The Wnt signaling pathway is classified into β-catenin-dependent (canonical) and -independent (non-canonical) pathways, both of which play pivotal roles in embryonic development and the regulation of many cellular functions. A close link between cancer and the canonical Wnt/β-catenin pathway has long been studied and growing evidence indicates that constitutive activation of the Wnt signaling by altered component of its pathway implicates in tumor growth, metastasis, angiogenesis, chromosome instability, cancer stemness, epithelial to mesenchymal transformation and immunomodulation of tumor microenvironment. Moreover, the Wnt pathway affects acquisition of resistance to molecular targeted drugs and immune checkpoint inhibitors. This special issue focuses on the role of Wnt signaling pathway in the tumorigenesis and therapeutic resistance in lung cancer.

22/12/2024