Discovery of novel cancer therapeutic targets and drugs

Despite significant progress made towards the identification of novel therapeutic targets and the discovery of potent chemotherapeutic agents, cancer incidence and mortality are rapidly growing worldwide, and it is one of the leading causes of death. Targeted therapies are one of the primary treatment strategies for cancers, especially after the cancer progresses to metastasis status. However, the intrinsic off-target toxicity of the current anticancer drugs as well as the rapid genetic evolution of cancer cells limited the therapeutic efficiency and led to the cancer eventually developing drug resistance. Thus, the identification of novel cancer therapeutic targets and the screening and development of cancer-targeted drugs are urgently needed. The aim of this special issue is to invite submissions of original articles and reviews tackling the discovery of novel cancer therapeutics targets and new drugs with potential anticancer activities. Studies employing in vitro cancer cell models and in vivo animal models with mechanism studies are welcome.

16/03/2025