Upregulated expression levels of ADAM10 and EGFR and downregulated expression levels of E-cadherin in hepatocellular carcinomas Retraction in /10.3892/etm.2014.1672

Yue,Yuan; Yang,Yumin; Shi,Lei; Wang,Zuoren

doi:10.3892/etm.2013.1340

December 2013 Volume 6 Issue 6

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December 2013 Volume 6 Issue 6

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Article

Upregulated expression levels of ADAM10 and EGFR and downregulated expression levels of E-cadherin in hepatocellular carcinomas

Retraction in: /10.3892/etm.2014.1672

Authors:
- Yuan Yue
- Yumin Yang
- Lei Shi
- Zuoren Wang
View Affiliations / Copyright

Affiliations: Department of Pharmacy, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, The Hospital of Luonan, Luonan, Shaanxi 726100, P.R. China, Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
Pages: 1380-1384
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Published online on: October 10, 2013

https://doi.org/10.3892/etm.2013.1340
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Abstract

The aim of this study was to investigate the expression and significance of a disintegrin and metalloproteinase 10 (ADAM10), epidermal growth factor receptor (EGFR) and E‑cadherin protein in hepatocellular carcinomas. The expression levels of ADAM10, EGFR and E‑cadherin were analyzed in 40 cases of hepatocellular carcinoma using immunohistochemistry and quantitative polymerase chain reaction (qPCR). The expression levels of ADAM10, EGFR and E-cadherin were significantly correlated with portal vein thrombosis, intrahepatic metastasis, differentiation degree and tumor size (P<0.05). In hepatocellular carcinoma, the expression levels of ADAM10 and EGFR were increased and the levels of E‑cadherin were decreased compared with those in the adjacent tissues. The elevated expression levels of ADAM10 and EGFR may be associated with the malignancy of the tumors. E‑cadherin expression is negatively correlated with the degree of malignancy. The detection of ADAM10, EGFR and E‑cadherin expression levels may contribute to an understanding of the oncogenesis and development of hepatocellular carcinomas.

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