The metabolic syndrome of fructose-fed rats: Effects of long-chain polyunsaturated ω3 and ω6 fatty acids. VII. Oxidative stress

Mellouk,Zoheir; Sener,Abdullah; Ait Yahia,Dalila; Malaisse,Willy  J.

doi:10.3892/mmr.2012.1093

December 2012 Volume 6 Issue 6

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December 2012 Volume 6 Issue 6

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Article

The metabolic syndrome of fructose-fed rats: Effects of long-chain polyunsaturated ω3 and ω6 fatty acids. VII. Oxidative stress

Authors:
- Zoheir Mellouk
- Abdullah Sener
- Dalila Ait Yahia
- Willy J. Malaisse
View Affiliations / Copyright

Affiliations: Department of Biology, Es-Sénia University, Es-Sénia 31100, Oran, Algeria, Laboratory of Experimental Hormonology, Université Libre de Bruxelles, B-1070 Brussels, Belgium
Pages: 1409-1412
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Published online on: September 20, 2012

https://doi.org/10.3892/mmr.2012.1093
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Abstract

In the present study, the plasma concentration, and liver, heart, kidney, soleus muscle and visceral adipose tissue content of thiobarbituric acid reactive substrates (TBARS), carbonyl radicals, hydroperoxides and nitric oxide were measured in control rats exposed for 8 weeks to a diet containing 64% (w/w) starch and 5% sunflower oil and in animals fed a diet containing 64% D-fructose and 5% sunflower oil or 3.4% sunflower oil mixed with 1.6% safflower or salmon oil. Coherent measurements of the plasma concentrations or tissue contents of these metabolites revealed increases in TBARS, carbonyl radical and hydroperoxide levels and a decrease in nitric oxide levels in the 5% sunflower oil‑fed rats. In the fructose-fed rats, the partial substitution of sunflower oil by either safflower or salmon oil minimized the changes. These findings provide further evidence in support of the favorable effects of the dietary supply of long-chain polyunsaturated ω6 and ω3 fatty acids upon the metabolic disturbances prevailing in the fructose-induced metabolic syndrome.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

The metabolic syndrome of fructose-fed rats: Effects of long-chain polyunsaturated ω3 and ω6 fatty acids. VII. Oxidative stress

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