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Article

Lack of association between the PIN1 promoter ‑667T>C (rs2233679) polymorphism and cancer risk: Evidence from meta‑analysis

  • Authors:
    • Liangjun Tao
    • Yisheng Chen
    • Lingsong Tao
    • Jian Kong
    • Haibo Qin
    • Jie Zheng
    • Bin Zou
    • Sizhong He
  • View Affiliations / Copyright

    Affiliations: Department of Urology and Institute of Prostatic Diseases, The Affiliated Wuhu No. 2 People's Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China, Department of Psychiatry, The Affiliated Wuhu No. 2 People's Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China
  • Pages: 223-228
    |
    Published online on: January 22, 2014
       https://doi.org/10.3892/br.2014.229
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Abstract

Peptidyl‑prolylcis‑trans isomerase NIMA-interacting 1 (PIN1) is a critical catalyst involved in multiple oncogenic signaling pathways. The PIN1 promoter ‑667T>C (rs2233679) polymorphism plays a role in cancer risk. The association between PIN1 (‑667T>C) polymorphism and cancer risk has been previously investigated. However, the available results are inconclusive. To derive a more precise estimation, a meta‑analysis of seven published case‑control studies including 4,524 cases with different tumor types and 4,561 controls was performed. Published literature from PubMed and EMBASE was retrieved. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the strength of the association. Overall, the results did not suggest any associations between the PIN1 promoter (‑667T>C) polymorphism and cancer susceptibility (OR=1.04, 95% CI: 0.91‑1.18 for CC vs. TT; OR=0.98, 95% CI: 0.89‑1.09 for TC vs. TT; OR=1.00, 95% CI: 0.91‑1.10 for TC/CC vs. TT; OR=1.07, 95% CI: 0.97‑1.18 for CC vs. TC/TT). Further stratified analysis by cancer type, ethnicity and sample size did not reveal any significant associations in the genetic models. The results of the present study demonstrate that the PIN1 promoter (‑667T>C; rs2233679) polymorphism is not associated with cancer susceptibility.
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Copy and paste a formatted citation
Spandidos Publications style
Tao L, Chen Y, Tao L, Kong J, Qin H, Zheng J, Zou B and He S: Lack of association between the PIN1 promoter ‑667T>C (rs2233679) polymorphism and cancer risk: Evidence from meta‑analysis. Biomed Rep 2: 223-228, 2014.
APA
Tao, L., Chen, Y., Tao, L., Kong, J., Qin, H., Zheng, J. ... He, S. (2014). Lack of association between the PIN1 promoter ‑667T>C (rs2233679) polymorphism and cancer risk: Evidence from meta‑analysis. Biomedical Reports, 2, 223-228. https://doi.org/10.3892/br.2014.229
MLA
Tao, L., Chen, Y., Tao, L., Kong, J., Qin, H., Zheng, J., Zou, B., He, S."Lack of association between the PIN1 promoter ‑667T>C (rs2233679) polymorphism and cancer risk: Evidence from meta‑analysis". Biomedical Reports 2.2 (2014): 223-228.
Chicago
Tao, L., Chen, Y., Tao, L., Kong, J., Qin, H., Zheng, J., Zou, B., He, S."Lack of association between the PIN1 promoter ‑667T>C (rs2233679) polymorphism and cancer risk: Evidence from meta‑analysis". Biomedical Reports 2, no. 2 (2014): 223-228. https://doi.org/10.3892/br.2014.229
Copy and paste a formatted citation
x
Spandidos Publications style
Tao L, Chen Y, Tao L, Kong J, Qin H, Zheng J, Zou B and He S: Lack of association between the PIN1 promoter ‑667T>C (rs2233679) polymorphism and cancer risk: Evidence from meta‑analysis. Biomed Rep 2: 223-228, 2014.
APA
Tao, L., Chen, Y., Tao, L., Kong, J., Qin, H., Zheng, J. ... He, S. (2014). Lack of association between the PIN1 promoter ‑667T>C (rs2233679) polymorphism and cancer risk: Evidence from meta‑analysis. Biomedical Reports, 2, 223-228. https://doi.org/10.3892/br.2014.229
MLA
Tao, L., Chen, Y., Tao, L., Kong, J., Qin, H., Zheng, J., Zou, B., He, S."Lack of association between the PIN1 promoter ‑667T>C (rs2233679) polymorphism and cancer risk: Evidence from meta‑analysis". Biomedical Reports 2.2 (2014): 223-228.
Chicago
Tao, L., Chen, Y., Tao, L., Kong, J., Qin, H., Zheng, J., Zou, B., He, S."Lack of association between the PIN1 promoter ‑667T>C (rs2233679) polymorphism and cancer risk: Evidence from meta‑analysis". Biomedical Reports 2, no. 2 (2014): 223-228. https://doi.org/10.3892/br.2014.229
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