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Article

Association between TGFB1 915G/C polymorphism and susceptibility to chronic hepatitis C virus infection: A meta‑analysis

  • Authors:
    • Guo‑Rui Hu
    • Bi‑Xia Zheng
    • Zhi‑Feng Liu
  • View Affiliations / Copyright

    Affiliations: Medical College of Nanjing University, Nanjing, Jiangsu 210093, P.R. China, Department of Digestive Disease, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China
  • Pages: 239-244
    |
    Published online on: January 24, 2014
       https://doi.org/10.3892/br.2014.230
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Abstract

The human transforming growth factor‑β1 (TGF‑β1) gene, namely TGFB1, contains several single‑nucleotide polymorphisms (SNPs) and some of the polymorphic variants were shown to affect the TGF‑β1 protein levels. A number of studies reported the association between 915G/C polymorphism and susceptibility to chronic hepatitis C virus (HCV) infection. However, the results were inconsistent. This meta‑analysis was conducted to assess the association of TGFB1 915G̸C polymorphism with susceptibility to chronic HCV infection. PubMed, ISI Web of Knowledge, ScienceDirect and Google Scholar databases were systematically searched up to August, 2013 to identify relevant studies. The pooled odds ratios (ORs) with their corresponding 95% confidence intervals (95% CIs) were calculated in 5 genetic comparison models (C vs. G, CC vs. GG, GC vs. GG, CC vs. GG+GC and CC+GC vs. GG). The Galbraith plot and subgroup analyses based on ethnicity, genotyping methods, sample size and fibrosis were performed to investigate possible sources of heterogeneity. A sensitivity analysis and assessment of publication bias were also conducted. Finally, 8 eligible case‑control studies on TGFB1 915G/C polymorphism, including a total of 910 cases and 632 controls, were included in this meta‑analysis. Overall, there was no evidence of any gene‑disease association obtained from the subgroup analyses. Therefore, this meta‑analysis demonstrated that there is no association between TGFB1 915G/C polymorphisms and susceptibility to chronic HCV infection.
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Copy and paste a formatted citation
Spandidos Publications style
Hu GR, Zheng BX and Liu ZF: Association between TGFB1 915G/C polymorphism and susceptibility to chronic hepatitis C virus infection: A meta‑analysis. Biomed Rep 2: 239-244, 2014.
APA
Hu, G., Zheng, B., & Liu, Z. (2014). Association between TGFB1 915G/C polymorphism and susceptibility to chronic hepatitis C virus infection: A meta‑analysis. Biomedical Reports, 2, 239-244. https://doi.org/10.3892/br.2014.230
MLA
Hu, G., Zheng, B., Liu, Z."Association between TGFB1 915G/C polymorphism and susceptibility to chronic hepatitis C virus infection: A meta‑analysis". Biomedical Reports 2.2 (2014): 239-244.
Chicago
Hu, G., Zheng, B., Liu, Z."Association between TGFB1 915G/C polymorphism and susceptibility to chronic hepatitis C virus infection: A meta‑analysis". Biomedical Reports 2, no. 2 (2014): 239-244. https://doi.org/10.3892/br.2014.230
Copy and paste a formatted citation
x
Spandidos Publications style
Hu GR, Zheng BX and Liu ZF: Association between TGFB1 915G/C polymorphism and susceptibility to chronic hepatitis C virus infection: A meta‑analysis. Biomed Rep 2: 239-244, 2014.
APA
Hu, G., Zheng, B., & Liu, Z. (2014). Association between TGFB1 915G/C polymorphism and susceptibility to chronic hepatitis C virus infection: A meta‑analysis. Biomedical Reports, 2, 239-244. https://doi.org/10.3892/br.2014.230
MLA
Hu, G., Zheng, B., Liu, Z."Association between TGFB1 915G/C polymorphism and susceptibility to chronic hepatitis C virus infection: A meta‑analysis". Biomedical Reports 2.2 (2014): 239-244.
Chicago
Hu, G., Zheng, B., Liu, Z."Association between TGFB1 915G/C polymorphism and susceptibility to chronic hepatitis C virus infection: A meta‑analysis". Biomedical Reports 2, no. 2 (2014): 239-244. https://doi.org/10.3892/br.2014.230
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