Measurement of hair iron concentration as a marker of body iron content
- Authors:
- Cem Sahin
- Cigdem Pala
- Leylagul Kaynar
- Yasemin Altuner Torun
- Aysun Cetin
- Fatih Kurnaz
- Serdar Sıvgın
- Fatih Serdar Sahin
View Affiliations
Affiliations: Department of Internal Medicine, Faculty of Medicine, Muğla Sitki Kocman University, Orhaniye, Muğla 48000, Turkey, Department of Hematology, Faculty of Medicine, Erciyes University, Melikgazi, Kayseri 38039, Turkey, Department of Pediatric Hematology, Education and Research Hospital, Kayseri, Kayseri 38010, Turkey, Department of Biochemistry, Faculty of Medicine, Erciyes University, Melikgazi, Kayseri 38039, Turkey, Graduate School of Health Sciences Stem Cell Sciences, Faculty of Medicine, Erciyes University, Melikgazi, Kayseri 38039, Turkey
- Published online on: January 27, 2015 https://doi.org/10.3892/br.2015.419
-
Pages:
383-387
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Abstract
The aim of the present study was to define the possible association between blood parameters and hair iron concentration in patient groups showing a difference in body iron content. The study population comprised subjects with iron deficiency anaemia and transfusion‑related anaemia with different body iron contents and a healthy control group. All the cases included in the study were examined with respect to hair iron concentration, serum iron, total iron‑binding capacity (TIBC), transferrin saturation and erythrocyte markers in the total blood count with ferritin values. Differences in hair iron concentration were evaluated between the groups. Correlation analysis was applied to define the association between the laboratory values used as markers of body iron content and hair iron concentration. A statistically significant difference was determined in hair iron 56Fe and 57Fe concentrations between the group with transfusion‑related anaemia, the iron deficiency anaemia group and the healthy control group (P<0.001). In addition, a positive correlation was determined between hair iron 56Fe and 57Fe concentrations and serum iron, ferritin level, transferrin saturation, mean erythrocyte volume and mean erythrocyte haemoglobin values and a negative correlation with TIBC. In conclusion, the results of the present study showed a statistically significant difference in the hair iron concentrations of the patient groups with different body iron content and these values were correlated to the laboratory markers of body iron content.
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