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A comparison between the impact of two types of dietary protein on brain glucose concentrations and oxidative stress in high fructose-induced metabolic syndrome rats

  • Authors:
    • Zohra Madani
    • Willy J. Malaisse
    • Dalila Ait‑Yahia

  • View Affiliations

  • Published online on: July 27, 2015     https://doi.org/10.3892/br.2015.498
  • Pages: 731-735
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Abstract

The present study explored the potential of fish proteins to counteract high glucose levels and oxidative stress induced by fructose in the brain. A total of 24 male Wistar rats consumed sardine protein or casein with or without high fructose (64%). After 2 months, brain tissue was used for analyses. The fructose rats exhibited an increase in body mass index (BMI), body weight, absolute and relative brain weights and brain glucose; however, there was a decrease in food and water intake. Fructose disrupts membrane homeostasis, as evidenced by an increase in the brain hydroperoxides and a decrease in catalase (CAT) and glutathione peroxidase (GSH‑Px) compared to the control. The exposure to the sardine protein reduced BMI, food intake, glucose and hydroperoxides, and increased CAT and GSH‑Px in the brain. In conclusion, the metabolic dysfunctions associated with the fructose treatment were ameliorated by the presence of sardine protein in the diet by decreasing BMI, brain glucose and lipid peroxidation, and increasing CAT and GSH-Px activities.
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September-2015
Volume 3 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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  • Journal Metrics
  • Impact Factor: 2.3
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  • CiteScore: 4.1
  • CiteScore Rank: Q1: #19/80 Pharmacology, Toxicology and Pharmaceutics
  • Source Normalized Impact per Paper (SNIP): 0.7
  • SCImago Journal Rank (SJR): 0.514
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Spandidos Publications style
Madani Z, Malaisse WJ and Ait‑Yahia D: A comparison between the impact of two types of dietary protein on brain glucose concentrations and oxidative stress in high fructose-induced metabolic syndrome rats. Biomed Rep 3: 731-735, 2015.
APA
Madani, Z., Malaisse, W.J., & Ait‑Yahia, D. (2015). A comparison between the impact of two types of dietary protein on brain glucose concentrations and oxidative stress in high fructose-induced metabolic syndrome rats. Biomedical Reports, 3, 731-735. https://doi.org/10.3892/br.2015.498
MLA
Madani, Z., Malaisse, W. J., Ait‑Yahia, D."A comparison between the impact of two types of dietary protein on brain glucose concentrations and oxidative stress in high fructose-induced metabolic syndrome rats". Biomedical Reports 3.5 (2015): 731-735.
Chicago
Madani, Z., Malaisse, W. J., Ait‑Yahia, D."A comparison between the impact of two types of dietary protein on brain glucose concentrations and oxidative stress in high fructose-induced metabolic syndrome rats". Biomedical Reports 3, no. 5 (2015): 731-735. https://doi.org/10.3892/br.2015.498