search button
Open Access

Age‑related changes in clinical parameters and their associations with common complex diseases

  • Authors:
    • Yoshiko Murakata
    • Tetsuo Fujimaki
    • Yoshiji Yamada

  • View Affiliations

  • Published online on: August 5, 2015     https://doi.org/10.3892/br.2015.505
  • Pages: 767-777

  • Copyright: © Murakata et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to clarify the age‑related changes in 13 clinical parameters and their associations with common complex diseases. Study subjects comprised 6,027 community‑dwelling individuals who were recruited to a population‑based longitudinal genetic epidemiological study. Bonferroni's correction was applied to compensate for multiple comparisons of association and P<0.0011 was considered statistically significant. Body mass index and waist circumference increased with age up to ~50 years and decreased thereafter in men, whereas the two parameters increased linearly with age in women. The prevalence of obesity was highest (41.1%) in men aged 40‑49 years, after which it decreased with age. The prevalence of obesity in women increased with age to ≤32.2% in those aged ≥70 years. Systolic and mean blood pressure (BP), as well as pulse pressure, increased linearly with age in all subjects, whereas diastolic BP increased with age up to ~60 years and subsequently decreased. The prevalence of hypertension increased with age to ≤69.9 or 68.5% at age ≥70 years in men and women, respectively. The fasting plasma glucose level, blood hemoglobin A1c content and the prevalence of type 2 diabetes mellitus increased gradually with age in men and women. The serum triglyceride concentration increased with age up to ~50 years and decreased thereafter in men, whereas it increased linearly with age in women. The prevalence of hypertriglyceridemia increased to a peak of 56.8% at age 50‑59 years and subsequently decreased in men, whereas in women it increased with age to ≤34.9% at ≥70 years. The serum high‑density lipoprotein (HDL)‑cholesterol concentration increased with age up to ~50 years and decreased thereafter in women. The prevalence of hypo‑HDL‑cholesterolemia increased gradually with age in women. The serum concentration of low‑density lipoprotein (LDL)‑cholesterol increased with age up to ~50 years and subsequently declined in men, whereas it increased linearly with age in women. The prevalence of hyper‑LDL‑cholesterolemia increased with age to ≤53.4% at 50‑59 years in men and ≤63.9% at 60‑69 years in women and it decreased thereafter in the two genders. The serum creatinine concentration and the estimated glomerular filtration rate increased or decreased linearly with age, respectively. The prevalence of chronic kidney disease (CKD) increased with age to ≤45.1 or 39.6% at ≥70 years in men and women, respectively. Therefore, these results indicate that 13 clinical parameters, as well as the prevalence of obesity, hypertension, type 2 diabetes mellitus, dyslipidemia and CKD, were significantly associated with age. They may therefore prove informative for the prevention of these diseases and contribute to the achievement of a healthy long life and successful aging.
View Figures
View References

Related Articles

Journal Cover

November-2015
Volume 3 Issue 6

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 2.3
  • Ranked
    (total number of cites)
  • CiteScore: 4.1
  • CiteScore Rank: Q1: #19/80 Pharmacology, Toxicology and Pharmaceutics
  • Source Normalized Impact per Paper (SNIP): 0.7
  • SCImago Journal Rank (SJR): 0.514
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Murakata Y, Fujimaki T and Yamada Y: Age‑related changes in clinical parameters and their associations with common complex diseases. Biomed Rep 3: 767-777, 2015.
APA
Murakata, Y., Fujimaki, T., & Yamada, Y. (2015). Age‑related changes in clinical parameters and their associations with common complex diseases. Biomedical Reports, 3, 767-777. https://doi.org/10.3892/br.2015.505
MLA
Murakata, Y., Fujimaki, T., Yamada, Y."Age‑related changes in clinical parameters and their associations with common complex diseases". Biomedical Reports 3.6 (2015): 767-777.
Chicago
Murakata, Y., Fujimaki, T., Yamada, Y."Age‑related changes in clinical parameters and their associations with common complex diseases". Biomedical Reports 3, no. 6 (2015): 767-777. https://doi.org/10.3892/br.2015.505